RecruitingNot ApplicableNCT06495463

Lonsurf® (Trifluridine/Tipiracil) Plus Chemotherapy in Metastatic Colorectal Cancer Prospective Study in Taiwan

The Efficacy of Lonsurf® (Trifluridine/Tipiracil) Plus Chemotherapy in Metastatic Colorectal Cancer: Multi-center Prospective Study in Taiwan


Sponsor

Chang Gung Memorial Hospital

Enrollment

110 participants

Start Date

Mar 19, 2022

Study Type

INTERVENTIONAL

Conditions

Summary

Primary Endpoint : To evaluate the Disease control rate (DCR) Secondary Endpoints: To evaluate the Progression-free survival (PFS), Overall survival(OS) and Safety profile


Eligibility

Plain Language Summary

Simplified for easier understanding

This study is looking at how well the drug Lonsurf (trifluridine/tipiracil) combined with chemotherapy works in patients in Taiwan with colorectal cancer that has spread and has already been treated with multiple standard therapies. **You may be eligible if...** - You have metastatic colorectal cancer confirmed by biopsy - You have already been treated with standard chemotherapy regimens including fluorouracil, oxaliplatin, irinotecan, and anti-VEGF therapy - If your tumor is RAS wild-type, you have also received anti-EGFR therapy - You have at least one measurable tumor lesion - You are in adequate physical condition to receive further chemotherapy **You may NOT be eligible if...** - You have not received the required prior therapies - You have serious organ dysfunction that would make chemotherapy unsafe - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGTrifluridine/tipiracil

Trifluridine/tipiracil 35 mg/m2 PO twice daily on days 1-5 and day 6-14 off (choose one combination) : oxalipatin 85mg/m2 IV on day 1 every 14 days or irinotecan 100mg/m2 IV on day 1 every 14 days.


Locations(1)

Chang-Gung Memorial Hospital, Linkou

Linkou District, Taiwan

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NCT06495463


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