Barrigel® PPRT (Post-Prostatectomy Radiation Therapy) Trial

This trial is studying whether injecting a biodegradable hydrogel spacer (Barrigel) between the rectum and the remaining prostate tissue before radiation therapy after prostatectomy (post-prostatectomy radiation) can protect rectal tissue and reduce side effects. **You may be eligible if...** - You are 18 or older - You have been treated with a radical prostatectomy (nerve-sparing) for prostate adenocarcinoma - Your prostate-specific antigen (PSA) level is 0.1 ng/mL or higher - There is no evidence of cancer spread beyond the prostate on imaging - You plan to receive post-prostatectomy radiation therapy **You may NOT be eligible if...** - Your prostatectomy was not nerve-sparing - You have evidence of cancer spread to lymph nodes or distant organs - You have had prior radiation to the pelvis - You have conditions that make the gel injection unsafe Talk to your doctor to see if this trial is right for you.