The Underlying Mechanisms Regarding the Effect of Glucagon on the Kidneys Will be Investigated in Healthy Males.
Renal Extraction of Glucagon and Renal Effects of Glucagon
Ali Asmar
10 participants
Feb 20, 2024
INTERVENTIONAL
Conditions
Summary
The goal of this crossover study is to investigate to what extend glucagon affects the kidneys. The main questions it aims to answer are: Does glucagon regulate kidney function through extraction in the kidney in addition to glomerular filtration? Does glucagon regulate kidney function by increasing renal plasma flow and glomerular filtration rate? Does glucagon regulate kidney function by increasing renal salt excretion?
Eligibility
Inclusion Criteria4
- Age: 20-60 years
- Normal health ascertained through questioning and medical examination
- Normal values for blood concentrations of fasting plasma glucose, fasting plasma total cholesterol, fasting triglycerides, HDL, LDL, creatinine, liver function, and electrolytes
- Informed consent
Exclusion Criteria7
- Immunosuppressive treatment in the preceding 12 months
- Alcohol abuse
- Medical treatment with oral glucocorticoids, dipeptidyl peptidase-4 (DPP-4) inhibitors, or GLP-1 receptor agonists, which, in the opinion of the investigator, may interfere with glucose metabolism
- Use of lithium
- Medical treatment that affects insulin secretion or cardiovascular performance measures
- Liver disease (ALT > 2x normal value)
- Renal impairment (se-creatinine > 130 μM and/or albuminuria)
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Interventions
Glucagon infusion of 5 ng·kg-1·min-1 from 0-60 minutes and 10 ng·kg-1 ·min-1 from 60-120 minutes.
Placebo (0.9% NaCl).
Glucagon (infusion of 5 ng·kg-1·min-1 from 0-60 minutes) and glucagon (infusion of 10 ng·kg-1 ·min-1 from 60-120 minutes) + a GLP-1R antagonist, exendin 9-39 (900 pmol·kg-1·min-1 from -30-120 minutes).
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06498063