Mifepristone vs Misoprostol
Mifepristone Versus Misoprostol for Cervical Preparation Prior to Procedural Abortion at 12 to 16 Weeks' Gestation in an Academic Medical Center: a Randomized Controlled Pilot Trial
Montefiore Medical Center
94 participants
Oct 31, 2024
INTERVENTIONAL
Conditions
Summary
The Investigator team hypothesizes that in a randomized trial comparing mifepristone-alone or misoprostol-alone for cervical preparation for procedural abortions at 12 to 16 weeks in hospital-based care, the proportion of patients who achieve successful cervical dilation will be different between the study groups.
Eligibility
Inclusion Criteria4
- English or Spanish-speaking
- Capacity to consent
- Seeking induced abortion of a singleton pregnancy
- Between 12 weeks, 0 days and 16 weeks, 6 days (based on age at day of surgery)
Exclusion Criteria9
- History of more than two prior Cesarean deliveries
- Sonographic evidence of placenta previa
- Sonographic concern for morbidly adherent placenta
- Prior obstetric hemorrhage requiring transfusion
- Obstructive cervical or lower uterine segment fibroid
- Current therapeutic anticoagulation use
- Cerclage in situ
- History of more than one prior cervical excisional procedure
- BMI greater than 50 kg/m\^2
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Interventions
200 milligrams (mg)
600 micrograms (ug)
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06502158