Salvage MR-guided High-Dose-Rate Brachytherapy for Prostate Bed Recurrence After Radiotherapy in the PSMA PET Scan Era

This study is testing a highly precise type of radiation treatment — MRI-guided high-dose-rate brachytherapy, where radioactive seeds are placed near the tumor — for men whose prostate cancer has come back in the prostate bed area after they previously received radiation therapy. **You may be eligible if...** - You are over 18 years old and have previously received radiation therapy to the prostate area - You have a confirmed recurrence of cancer in the prostate bed (confirmed by biopsy, MRI, or a specialized PSMA PET scan) - Your PSA level has risen on at least two consecutive tests and is above 0.2 ng/dL - Your PSA doubling time from its lowest point is more than 6 months - You are in good overall health (ECOG 0–2) **You may NOT be eligible if...** - Scans show that cancer has spread to distant parts of the body - You had severe bowel or urinary side effects from your previous radiation - You have contraindications to MRI (e.g., certain metal implants) Talk to your doctor to see if this trial is right for you.