CT-Angiography Plaque Characteristics and Events in Deferral Patients by Invasive Fractional Flow Reserve
CT-Angiography-Derived Plaque Characteristics on Cardiac Events in Deferral Patients by Invasive Fractional Flow Reserve
Fujita Health University
400 participants
Jan 30, 2025
OBSERVATIONAL
Conditions
Summary
Fractional flow reserve (FFR)-guided PCI for chronic coronary syndromes (CCS) is reported to improve the outcomes compared with angiography-guided PCI. However, cardiac-events still occur in FFR-deferral patients in long-term follow-up. Coronary computed tomography angiography (CTA)-defined high-risk-plaque (HRP) is known to relate future cardiac events. The investigators hypothesized that CTA might identify plaque features linked to future cardiac events in deferral patients.
Eligibility
Inclusion Criteria3
- men and women aged ≥20 years,
- patients having chronic coronary syndromes (CCS,
- Coronary computed tomography angiography (CTA) was performed within 90 days before invasive coronary angiography (ICA) with fractional flow reserve (FFR) pressure measurement.
Exclusion Criteria3
- patients with a history of coronary bypass grafting (CABG) because CABG changed local coronary flow dynamics,
- patients with left-main disease,
- patients with fractional flow reserve (FFR) in stented vessels due to inability to estimate plaque morphology in the stented lesion by coronary computed tomography angiography.
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Interventions
A consecutive series of patients who underwent Coronary computed tomography angiography (CTA) within 90 days before invasive coronary angiography (ICA) with fractional flow reserve (FFR) pressure measurement were candidates for this study at Fujita Health University Hospital, Bantane Hospital, and Nagoya First Red Cross Hospital
Locations(1)
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NCT06508697