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RecruitingNCT06509659

Methacholine Challenge Test (MCT) in Healthy Adults

Methacholine Challenge Test (MCT) in Healthy Adults: Oscillometry Measured Alone Compared to Oscillometry and FEV1 During the Same Test

Sponsor

Allergi- og Lungeklinikken, Elsinore

Enrollment

25 participants

Start Date

Aug 10, 2024

Study Type

OBSERVATIONAL

Conditions

Hyperreactive Airway Disease

Summary

Knowledge of Methacholine Challenge Test (MCT) and impedance Oscillometry (IOS) is limited. Only three studies have included adult patients, and none of these with healthy controls. The three studies have combined IOS and spirometry in the same test, although it is not recommended to perform IOS after a test that requires deep breathing, e.g. FEV1 measurement. Deep breathing is considered to affect the impedance via reduced tone in the smooth muscle.

Eligibility

Min Age: 18 YearsMax Age: 65 Years

Inclusion Criteria5

  • Forced expiratory volume in the 1. second (FEV1) >80%
  • FEV1/FVC-ratio >0,7
  • FeNO <25 pbb
  • Oxygen saturation (SatO2) >95%
  • Negative methacholine Challenge Test = drop in FEV1 less than 20%

Exclusion Criteria6

  • Any lung disease
  • Lung symptoms
  • Medicine for lung disease
  • Tobacco smoking
  • Ex-smokers with more than 5 package years
  • BMI (body mass index) >40 kg/m2

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Interventions

DIAGNOSTIC_TESTMethacholine Challenge Test

MCT with IOS alone versus MCT IOS and FEV1 combined

Locations(1)

Thomas Ringbæk

Elsinore, Denmark

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NCT06509659