RecruitingNCT06513650
Mechanism-based Therapy of Hypotensive Syncope
Sponsor
Istituto Auxologico Italiano
Enrollment
140 participants
Start Date
May 1, 2024
Study Type
OBSERVATIONAL
Conditions
Summary
The aim of this study is to assess the efficacy of a therapeutic strategy aimed to increase 24-hour systolic blood pressure (SBP) values, assessed by 24-hour ambulatory blood pressure monitoring (ABPM), in reducing syncope recurrences in patients affected by hypotensive syncope during one year of follow-up.
Eligibility
Min Age: 18 Years
Inclusion Criteria4
- Patients \>18-year-old with a clinical diagnosis of severe, recurrent reflex syncope, refractory to education and life-style measures (according to the criteria of ESC guidelines) AND a diagnosis of hypotensive syncope defined as:
- Persistent or intermittent hypotension during 24-hour ABPM (ABPM1) AND/OR
- Reproduction of syncope during the Short Cardiovascular Autonomic Function Assessment (SCAFA) that consists in carotid sinus massage (CSM), 3-min active stand test, and head-up tilt test (TT) performed one after another in an uninterrupted sequence as a single procedure in a tilt table.
- \. Clinical indication to deprescribing of antihypertensive drugs or to prescribing of fludrocortisone therapy, as appropriate, according to the clinical practice of the investigator
Exclusion Criteria1
- \-
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Locations(9)
View Full Details on ClinicalTrials.gov
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NCT06513650