RecruitingNot ApplicableNCT06514703

Comparative Study of CT and Fluoroscopic Guided Genicular Nerve Ablation in the Treatment of Knee Osteoarthritis

Sponsor

Zagazig University

Enrollment

60 participants

Start Date

Sep 29, 2024

Study Type

INTERVENTIONAL

Conditions

Osteoarthritis, Knee

Summary

The goal of this study is to evaluate the comparative effectiveness of CT-guided and fluoroscopic-guided genicular nerve ablation in reducing knee pain and improving function in adults diagnosed with knee osteoarthritis refractory to conservative treatment. The main questions it aims to answer are: * Does CT-guided genicular nerve ablation provide superior pain relief compared to fluoroscopic-guided genicular nerve ablation? * Is there a significant difference in functional improvement between the two techniques? Researchers will compare the outcomes between the CT-guided and fluoroscopic-guided groups to determine which method achieves better pain relief, functional enhancement, safety profile, and patient satisfaction. Participants will: * Undergo either CT-guided or fluoroscopic-guided genicular nerve ablation. * Attend scheduled follow-up visits to assess pain levels, knee function, and any adverse events. * Complete standardized questionnaires to provide feedback on pain relief, functional improvement, and overall satisfaction with the procedure.

Eligibility

Min Age: 45 YearsMax Age: 80 Years

Inclusion Criteria5

Adults aged 45 to 80 years.
Diagnosed with knee osteoarthritis.
Knee osteoarthritis refractory to conservative treatment.
Able to provide informed consent.
Agree to follow the study procedures and attend follow-up visits.

Exclusion Criteria5

Prior knee surgery within the last six months.
Contraindications to genicular nerve ablation (e.g., certain types of infections, bleeding disorders).
Severe comorbid conditions that may interfere with the study outcomes (e.g., rheumatoid arthritis, other severe autoimmune diseases).
Current participation in another clinical trial that could interfere with the outcomes of this study.
Allergy or sensitivity to the materials used in the ablation procedures.

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Interventions

PROCEDURECT-Guided Genicular Nerve Ablation

This procedure involves using computed tomography (CT) imaging to guide the precise placement of a needle for the ablation of genicular nerves in the knee. The goal is to disrupt the pain signals caused by osteoarthritis, providing long-term pain relief. The intervention is performed under local anesthesia and is aimed at patients who have not responded adequately to conservative pain management strategies.

PROCEDUREFluoroscopic-Guided Genicular Nerve Ablation

This procedure utilizes fluoroscopy to accurately guide the needle placement for the ablation of genicular nerves associated with osteoarthritis knee pain. The technique focuses on minimizing pain and improving functional mobility by disrupting nerve pathways that transmit pain signals. Like the CT-guided approach, it is intended for use in patients whose symptoms have not been sufficiently managed with non-invasive treatments.