RecruitingNot ApplicableNCT06515262

Safety and Efficacy of Anti-BCMA-GPRC5D CAR-T Cells Therapy in the Treatment of r/r MM

A Clinical Study to Evaluate the Safety and Efficacy of BCMA-GPRC5D CAR-T in Patients With Relapsed/Refractory Multiple Myeloma Who Received Three or More Lines of Therapy


Sponsor

920th Hospital of Joint Logistics Support Force of People's Liberation Army of China

Enrollment

10 participants

Start Date

Jul 1, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

This is a single-center, open-label, single-arm study to evaluate the safety and efficacy of bispecific BCMA-GPRC5D CAR-T cells in patients with relapsed or refractory multiple myeloma who received three or more lines of therapy.


Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a CAR-T cell therapy targeting two proteins (BCMA and GPRC5D) found on myeloma cells, for people with relapsed or hard-to-treat multiple myeloma who have already tried multiple prior treatments including at least one proteasome inhibitor, one immunomodulatory drug, and one anti-CD38 antibody. **You may be eligible if...** - You are between 18 and 75 years old with a confirmed diagnosis of multiple myeloma - Your disease has relapsed or is refractory after at least 3 prior lines of therapy - You have measurable disease (detectable M-protein, free light chains, or related markers) - Your physical performance is adequate - Your organ function meets the required thresholds **You may NOT be eligible if...** - You have not failed at least 3 prior treatment lines - You have severe uncontrolled infection - You have significant heart, liver, kidney, or lung problems - You are pregnant or breastfeeding - You are currently enrolled in another clinical trial Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BIOLOGICALAnti-BCMA-GPRC5D CAR-T cells infusion

Subiects who meet the enrollment conditions will receive intravenous infusion of anti-BCMA-GPRC5D CAR-T Cells after lymphodepleting therapy.


Locations(1)

Sanbin Wang

Kunming, Kunming, Yunnan, China

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NCT06515262


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