RecruitingPhase 1Phase 2NCT06517888

Anti-VEGF Gene Therapy Trial for Vestibular Schwannoma

A Phase 1/2 Trial of AAVAnc80-antiVEGF Gene Therapy in Individuals With Unilateral Vestibular Schwannoma

Sponsor

Akouos, Inc.

Enrollment

27 participants

Start Date

Jan 17, 2025

Study Type

INTERVENTIONAL

Conditions

Vestibular Schwannoma

Summary

This trial will evaluate the safety and tolerability of a single unilateral administration of one of three dose levels of AAVAnc80-antiVEGF and will evaluate the Akouos delivery device to safely achieve the intended product performance.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying AAVAnc80-antiVEGF via Akouos Delivery Device for people with vestibular schwannoma. The study is currently recruiting participants at 4 locations. People eligible for this study include aged 18 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

COMBINATION_PRODUCTAAVAnc80-antiVEGF via Akouos Delivery Device

AAVAnc80-antiVEGF is a sterile suspension intended to be administered via intracochlear administration as a single dose using the Akouos Delivery Device

Locations(4)

Johns Hopkins Hospital

Baltimore, Maryland, United States

Mayo Clinic

Rochester, Minnesota, United States

Vanderbilt Bill Wilkerson Center

Nashville, Tennessee, United States

University of Texas Southwestern

Dallas, Texas, United States

View Full Details on ClinicalTrials.gov

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NCT06517888

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