RecruitingPhase 1Phase 2NCT06518551

Elotuzumab + Iberdomide + Dexamethasone Post Ide-Cel in RRMM

A Phase I/II Study of Elotuzumab and Iberdomide and Dexamethasone Post Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma


Sponsor

Omar Nadeem, MD

Enrollment

49 participants

Start Date

Nov 1, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

The aim of this research study is to evaluate the efficacy of Elotuzumab and Iberdomide therapy post-Idecabtagene Vicleucel in participants with relapsed and refractory multiple myeloma. The names of the study drugs involved in this study are: * Iberdomide (a type of cereblon E3 ligase modulator) * Elotuzumab (a type of monoclonal antibody) * Dexamethasone (a type of steroid)


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a three-drug combination — elotuzumab (an immunotherapy), iberdomide (a newer immune-modulating drug), and dexamethasone (a steroid) — in people with relapsed or refractory multiple myeloma (a blood cancer of plasma cells) who previously received a CAR-T cell therapy called ide-cel (idecabtagene vicleucel). **You may be eligible if...** - You have multiple myeloma that has come back or stopped responding to treatment - You have previously been treated with at least 4 prior lines of therapy, including certain standard drug classes (a proteasome inhibitor, an immunomodulatory drug, and an anti-CD38 antibody) - You previously received ide-cel CAR-T cell therapy - You are willing and able to provide written informed consent **You may NOT be eligible if...** - You have active, uncontrolled infections or certain heart, liver, or kidney problems - You have previously been treated with iberdomide - You have active central nervous system involvement from myeloma Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGElotuzumab

Humanized, recombinant IgG1 monoclonal antibody, 400- and 300-mg single-use vials, via intravenous (into the vein) infusion per protocol.

DRUGIberdomide

A cereblon E3 ligase modulator, 0.15mg, 0.2mg, 0.3mg, 0.45mg, 0.6, and 0.75 mg strength capsule taken orally per protocol.

DRUGDexamethasone

Synthetic adrenocortical steroid, 2 and 4 mg tablets, taken orally per standard of care.


Locations(3)

Brigham and Women's Hospital

Boston, Massachusetts, United States

Beth Israel Deaconess Medical Center

Boston, Massachusetts, United States

Dana Farber Cancer Institute

Boston, Massachusetts, United States

View Full Details on ClinicalTrials.gov

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NCT06518551


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