RecruitingNCT06519747

DETECTion of PeriOperative Atrial Fibrillation After Noncardiac Surgery

Enhanced DETECTion of PeriOperative Atrial Fibrillation After Noncardiac Surgery with Continuous Electrocardiographic Monitoring

Sponsor

Population Health Research Institute

Enrollment

750 participants

Start Date

Oct 15, 2024

Study Type

OBSERVATIONAL

Conditions

Atrial Fibrillation Atrial Flutter

Summary

This is a multicentre prospective cohort study where patients will receive up to 14 days of continuous ECG monitoring by wearing a portable monitoring device, starting within 72 hours after noncardiac surgery.

Eligibility

Min Age: 18 YearsMax Age: 120 Years

Inclusion Criteria8

Had undergone noncardiac surgery within the past 72 hours and requiring, or expected to require, at least one of the following:
an overnight hospital admission after surgery
day surgery that would result in a large enough physiological insult to be able to cause POAF. Procedures excluded include those that are conducted using local anesthesia alone, are less than 30 minutes in duration, and/or are judged to be of low physiologic insult by the local investigator.
Have one of the following high-risk criteria;
age 55-64 years, and having either established cardiovascular disease, recent major vascular surgery, a CHA2DS2-VASc score ≥3, or an elevated postoperative troponin level;
age 65-74 years, and having either established cardiovascular disease, recent major vascular surgery, a CHA2DS2-VASc score ≥2, or an elevated postoperative troponin level; or
age ≥75 years;
Provide written informed consent to participate.

Exclusion Criteria15

History of documented chronic (i.e., non-transient) AF before noncardiac surgery;
Need for long-term systemic anticoagulation;
Ongoing need for long-term dual antiplatelet treatment;
Contraindication to oral anticoagulation;
Severe renal insufficiency;
Severe liver cirrhosis;
Acute stroke in the past 14 days;
Underwent cardiac surgery in the past 35 days;
History of nontraumatic intracranial, intraocular, or spinal bleeding;
Hemorrhagic disorder or bleeding diathesis;
Known life expectancy \<1 year due to concomitant disease;
Women who are pregnant, breastfeeding, or of childbearing potential not taking effective contraception;
Expected to be non-compliant with follow-up and/or device use;
Known contact allergy to monitoring device and/or its peripheral components;
Previously enrolled in DETECT-POAF.