RecruitingEarly Phase 1NCT06520982
Early Neurovascular Adaptations in Aging Women
Sponsor
University of Missouri-Columbia
Enrollment
64 participants
Start Date
Sep 20, 2024
Study Type
INTERVENTIONAL
Conditions
Summary
Our goal is to enhance our understanding of early vascular adaptations in aging women with an emphasis on the sympathetic nervous system.
Eligibility
Sex: FEMALEMin Age: 18 YearsMax Age: 70 Years
Inclusion Criteria2
- Assigned female at birth (AFAB)
- years of age
Exclusion Criteria12
- Assigned male at birth (AMAB)
- Pregnancy, breastfeeding
- Body mass index ≥30 kg/m2
- Taking medications known to affect metabolic, autonomic, and/or respiratory function
- Oral hormonal contraception in last 6 month
- History of hormone replacement therapy
- History of hyster- or oophor-ectomy
- Current smoking/Nicotine use
- Increased risk of bleeding, pro-coagulant disorders, clotting disorders, anticoagulation therapy
- Chronic disease
- Blood pressure ≥140/90 mmHg
- Communication barriers
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Interventions
DRUGNorepinephrine
Infused intra-arterially in a dose-response fashion
DRUGIsoproterenol
Infused intra-arterially in a dose-response fashion
DRUGAcetylcholine
Infused intra-arterially in a dose-response fashion
DRUGNitroprusside
Infused intra-arterially in a dose-response fashion
DRUGEstrogen
Infused intra-arterially
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06520982
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