Salvage Stereotactic Body Radiotherapy of the Prostate Bed for Biochemical Recurrence After Radical Prostatectomy.

This study is comparing two approaches to radiation therapy for men whose prostate cancer has returned after prostate removal surgery (radical prostatectomy). The standard approach delivers many small doses of radiation over several weeks; the study approach (stereotactic body radiotherapy, or SBRT) delivers fewer, larger doses over a shorter time. Researchers want to see if the shorter course is just as effective with fewer side effects. **You may be eligible if...** - You had prostate cancer treated with prostate removal surgery (radical prostatectomy) - Your PSA (a prostate cancer marker in the blood) is rising after surgery, suggesting the cancer may have returned in the prostate area - You are 18 or older with good overall health (WHO performance status 0–1) - Your latest PSA is 2 ng/mL or below - You have no signs of cancer spread beyond the prostate area on imaging **You may NOT be eligible if...** - Your cancer spread to lymph nodes or has distant metastases - You have had prior radiation to the pelvis - Your prostate cancer is the highest-grade (Gleason 10) type - You have inflammatory bowel disease or certain other pelvic conditions - You have already received hormone therapy for more than 6 weeks before this trial - Your urinary symptoms score is very high (IPSS > 20) Talk to your doctor to see if this trial is right for you.