RecruitingNCT06525259

DISCOVERY of Risk Factors for Type 2 Diabetes in Youth

Sponsor

George Washington University

Enrollment

3,600 participants

Start Date

Oct 1, 2024

Study Type

OBSERVATIONAL

Conditions

Diabetes Mellitus Type 2, Childhood-Onset

Summary

The goal of the DISCOVERY study is to provide innovative critical information regarding the unique natural history of glycemic control, insulin sensitivity, and β-cell function, and their mechanistic determinates, in obese adolescents at risk for developing type 2 diabetes.

Eligibility

Min Age: 8 YearsMax Age: 15 Years

Plain Language Summary

Simplified for easier understanding

This study is looking for early risk factors for type 2 diabetes in children and teenagers who are at elevated risk — particularly those who are overweight or obese and have slightly elevated blood sugar. Researchers hope to understand the biological and environmental factors that predict which young people are most likely to develop diabetes, so that earlier interventions can be developed. **You may be eligible if...** - You are a child or teenager (girls aged 8–13; boys aged 9–15) - Your BMI is at or above the 85th percentile for your age (overweight or obese) - Your HbA1c is between 5.5–6.4% (prediabetes range) - You are at Tanner puberty stage 2, 3, or 4 **You may NOT be eligible if...** - You already have diabetes (HbA1c of 6.5% or higher) - You have a medical condition that affects blood sugar or puberty development - You are currently using insulin, metformin, GLP-1 agonists, or other glucose-lowering medications - You have had or are planning bariatric surgery - You are pregnant or planning to become pregnant - You do not speak English or Spanish Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Locations(20)

University of Alabama at Birmingham

Birmingham, Alabama, United States

Arizona State University

Phoenix, Arizona, United States

Phoenix Children's

Phoenix, Arizona, United States

Children's Hospital Los Angeles

Los Angeles, California, United States

Children's Hospital Colorado

Aurora, Colorado, United States

Johns Hopkins All Children's Hospital

St. Petersburg, Florida, United States

Johns Hopkins University School of Medicine

Baltimore, Maryland, United States

Boston Children's/Joslin Diabetes Center/Massachusetts General Hospital

Boston, Massachusetts, United States

Colorado Navajo Nation

Shiprock, New Mexico, United States

NYU Langone Health- Brooklyn

Brooklyn, New York, United States

NYU Langone Health- Long Island

Garden City, New York, United States

NYU Langone Health- Manhattan

New York, New York, United States

Albert Einstein College of Medicine

The Bronx, New York, United States

Atrium Health

Charlotte, North Carolina, United States

Wake Forest University

Winston-Salem, North Carolina, United States

Cincinnati Children's Hospital

Cincinnati, Ohio, United States

Nationwide Children's Hospital

Columbus, Ohio, United States

The University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, United States

Children's Hospital of Philadelphia

Philadelphia, Pennsylvania, United States

Baylor College of Medicine / Texas Children's

Houston, Texas, United States

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

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NCT06525259

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