Investigations of Reproductive Cancers in Women

This study is testing a new diagnostic tool to detect endometrial (uterine) cancer or other causes of abnormal uterine bleeding in women who are being worked up for this symptom. The device collects samples non-invasively, and researchers hope it can detect cancer markers early — potentially offering a less invasive alternative to current diagnostic procedures. **You may be eligible if...** - You are a woman aged 45 or older (most participants will be over 50) - You still have a uterus - You are currently being evaluated for abnormal uterine bleeding (AUB) or post-menopausal bleeding (PMB) - You are able to complete study visits and be contacted by phone during the study **You may NOT be eligible if...** - You have had a hysterectomy (uterus removed) - You have a known history of endometrial cancer or uterine sarcoma - You have previously been treated for endometrial cancer - You are suspected to be pregnant - You have used a tampon within 7 days of sample collection Talk to your doctor to see if this trial is right for you.