Clinical Characteristics and Prognosis of Acute Stroke in Pregnancy and Puerperium
Clinical Characteristics and Prognosis of Acute Stroke in Pregnancy and Puerperium: A Retrospective, Observational, Nationwide, Multicenter Study
Beijing Tiantan Hospital
1,200 participants
Jul 31, 2024
OBSERVATIONAL
Conditions
Summary
The objectives of this study are: (1) to describe the detailed clinical characteristics and prognosis of ASPP patients in order to explore the risk factors of ASPP, and to compare the short-term and long-term functional recovery outcomes between them and their controls; (2) to evaluate the risk of recurrent stroke, particularly during subsequent pregnancies, in ASPP patients; (3) to assess the short-term and long-term outcomes of their offsprings and their future development status. This study is divided into three parts. The first part is a case-control study to explore the risk factors of ASPP and the predictors of the prognosis of ASPP patients. The second part is a cohort study to evaluate the impact of ASPP on the risk of recurrent stroke. The third part is a cohort study to assess the impact of ASPP on the short-term and long-term outcomes of their offsprings by comparing the offsprings of ASPP patients with the offsprings of non-ASPP participants.
Eligibility
Inclusion Criteria6
- \. Case-control Study and Cohort Study on Recurrent Stroke Risk:
- Female patients ≥18 years of age;
- Patients or their legally acceptable representatives or relatives agree to collect personal information for this study and sign an oral or online written informed consent.
- Female patients ≥18 years of age;
- Patients in pregnancy or within 6 weeks postpartum;
- Patients or their legally acceptable representatives or relatives agree to collect personal information for this study and sign an oral or online written informed consent.
Exclusion Criteria10
- Patients or their legally acceptable representatives or relatives refuse follow-up;
- Patients missing critical baseline demographic, clinical or neuroimaging data.
- \. Cohort Study on Offspring Outcomes:
- Patients or their legally acceptable representatives or relatives refuse follow-up;
- Patients missing critical baseline demographic, clinical or neuroimaging data;
- Patients whose offsprings have congenital malformation or inborn error of metabolism;
- Patients with complications which may affect cerebral blood flow supply, such as amniotic fluid embolism, in pregnancy;
- Patients whose family members other than the parents and siblings of their offsprings have a history of severe mental illness, such as mental retardation, autism and schizophrenia;
- Patients undergo acute myocardial infarction in pregnancy;
- Patients undergo non-spontaneous stroke events due to other causes, such as cerebral infarction or hemorrhage caused by surgery.
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Locations(1)
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NCT06527807