RecruitingPhase 2Phase 3NCT06529029

Low Amplitude Pulse Seizure Therapy Versus Standard Ultra-Brief Right Unilateral Electroconvulsive Therapy

Efficacy of Low Amplitude Pulse Seizure Therapy Versus Standard Ultra-Brief Right Unilateral Electroconvulsive Therapy in Remission of Suicidal Ideation

Sponsor

Michigan State University

Enrollment

30 participants

Start Date

Jul 3, 2024

Study Type

INTERVENTIONAL

Conditions

Suicidal Ideation Major Depressive Disorder Bipolar Disorder Schizo Affective Disorder

Summary

This protocol proposes an initial randomized clinical trial that includes all patients with suicidal ideation (SI) at baseline, and with SI as the primary outcome measure to examine whether Right Unilateral Low-Amplitude Pulse - Seizure Therapy (RUL LAP-ST) treatment has more magnitude and rate of remission of SI as conventional pulse amplitude Right Unilateral Electroconvulsive Therapy (RUL ECT) (based on our prior secondary analysis). Our central hypothesis is that RUL LAP-ST has significantly less cognitive/memory side effects (no memory side effects were noted in our prior studies for 500mA and 600mA) and thus is more favorable in terms of side effects compared to RUL conventional pulse amplitude ECT, while maintaining better anti-suicidal effect.

Eligibility

Min Age: 18 YearsMax Age: 90 Years

Plain Language Summary

Simplified for easier understanding

This study is comparing two types of electroconvulsive therapy (ECT) — a standard brief-pulse ECT and a newer low-amplitude pulse version — to see which is more effective with fewer side effects (like memory loss) for people with severe depression or other conditions where ECT is recommended. **You may be eligible if...** - Your psychiatrist has already recommended ECT as part of your treatment - You have a psychiatric condition (such as severe depression) for which ECT is clinically indicated - You are willing to participate in the study **You may NOT be eligible if...** - You have a medical reason that makes ECT unsafe - You are unable to give informed consent - Your condition does not meet criteria for ECT referral Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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