RecruitingPhase 2NCT06529523

Tislelizumab in People With Colorectal Cancer

PD-1 (Programmed Cell Death Protein 1) Blockade in Mismatch-repair Deficient Colorectal Cancer in Nigeria


Sponsor

Memorial Sloan Kettering Cancer Center

Enrollment

40 participants

Start Date

Jul 26, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

The researchers are doing this study to find out whether tislelizumab is an effective treatment for people with colorectal cancer who are living in Nigeria. The researchers will also look at the safety of the study drug. All participants in this study will be treatment naïve (they have not yet received treatment for their cancer), and their cancer will be mismatch repair deficient (dMMR). dMMR cancer can happen when your cells are unable to repair mistakes made during the cell division process.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing an immunotherapy drug called tislelizumab in patients with colorectal cancer. Immunotherapy works by helping the immune system recognize and attack cancer cells, and this trial evaluates how well it works and how safe it is in this cancer type. **You may be eligible if...** - You are 18 years or older - You are in good physical condition (able to carry out normal activities) - You have a confirmed diagnosis of colorectal cancer - Women of childbearing age must have a negative pregnancy test and use contraception **You may NOT be eligible if...** - You are pregnant or breastfeeding - You have serious autoimmune conditions - You have had prior treatment that would make immunotherapy unsafe - Your physical condition is too poor for treatment Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGTislelizumab

Patients will receive standard dose of tislelizumab 200mg IV flat dose q3weeks until disease progression, unacceptable toxicity, patient/physician decides to withdraw patient, death, or completion of 104 weeks treatment (35 administrations).


Locations(3)

Memorial Sloan Kettering Cancer Center

New York, New York, United States

Lagos University Teaching Hospital

Idi Araba, Lagos, Nigeria

Obafemi Awolowo University Teaching Hospital

Ile-Ife, Nigeria

View Full Details on ClinicalTrials.gov

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NCT06529523


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