Gut Microbiota in Chronic GI Diseases
The Role of Gut Microbiota in Chronic GI Diseases: A Pilot Study
McMaster University
260 participants
Oct 1, 2012
OBSERVATIONAL
Conditions
Summary
The study involves characterizing the microbiota of patients with IBS, functional diarrhea, IBD, severe motility disorders and celiac disease. This will be complemented by a translational phase of human-mouse hybrid experiments in which germ-free mice will be colonized with feces from these patients with different GI disease and non-disease controls and we will compare symptoms, microbiota composition and histological changes in the gut and in the brain of the mice.
Eligibility
Inclusion Criteria3
- Diagnosis of IBD, active celiac disease (aTTG positive + endoscopic view and histological findings compatible), IBS (Rome IV criteria or physician diagnosis) severe motility disorders (severe constipation, severe functional dyspepsia) gluten sensitivity (IBS diarrhea predominant with positive anti gliadin antibodies and negative aTTG), functional diarrhea (Rome IV criteria), anal fissure and/or fistula or non-disease control individual or 1st degree family member of celiac patient.
- Willingness to participate
- Signed Informed Consent
Exclusion Criteria2
- Antibiotics in the last month
- Probiotics in the previous month
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Interventions
Esophagogastroduodenoscopy and colonoscopy with video recording and biopsy collection
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06532110