RecruitingNCT06533709

Satisfactory Debulking Prediction Model for Advanced Ovarian Cancer Based on PET-CT Image Data

Satisfactory Debulking Prediction Model for Advanced Ovarian Cancer Based on PET-CT Image Data and Its Clinical Application


Sponsor

Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

Enrollment

146 participants

Start Date

Jun 1, 2024

Study Type

OBSERVATIONAL

Conditions

Summary

This project intends to conduct a multicenter retrospective study to evaluate the satisfactory reduction of advanced ovarian cancer using PET-CT images, and explore the correlation between molecular biological characteristics and clinical characteristics of ovarian cancer through high-throughput sequencing genomics combined with radiomics.


Eligibility

Sex: FEMALEMin Age: 18 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study aims to build a computer model that uses PET/CT scan images to predict — before surgery — whether a surgeon will be able to remove most or all of an advanced ovarian cancer tumor (called satisfactory debulking). Achieving good surgical removal is one of the most important factors in ovarian cancer outcomes. Better prediction tools could help surgeons and patients make more informed decisions about the timing and approach of surgery. **You may be eligible if...** - You have epithelial ovarian cancer (the most common type, originating from the surface cells of the ovary) - You underwent primary debulking surgery (surgery to remove as much tumor as possible) at the participating hospital - Your cancer was confirmed as FIGO stage IIB or higher (meaning it has spread beyond the ovary) - Your clinical, surgical, and pathological records are largely complete **You may NOT be eligible if...** - You have a non-epithelial ovarian cancer (such as germ cell or sex cord-stromal tumors) - You had fertility-preserving or palliative (non-curative) surgery - You had an active infection at the time of your PET/CT scan - You had another concurrent cancer - You had severe disease in other major organs Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTRadio-score

A score based on the LASSO regression model predicting the R0 resection of the primary debulking surgery of advanced ovarian cancer.


Locations(1)

The Sun Yat-sen Memorial Hospital of Sun Yat-sen University

Guangzhou, Guangdong, China

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NCT06533709


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