RecruitingNCT06533813

Clinical Epidemiology in Contemporary Patients With Myelofibrosis.

Clinical Epidemiology in Contemporary Patients With Myelofibrosis (ERNEST-3): A European LeukemiaNet (ELN) Observational Study

Sponsor

FROM- Fondazione per la Ricerca Ospedale di Bergamo- ETS

Enrollment

617 participants

Start Date

Oct 14, 2024

Study Type

OBSERVATIONAL

Conditions

Myelofibrosis

Summary

Multicenter retrospective and prospective European observational study. At each site, all consecutive patients with a 2016- or 2022 World Health Organization (WHO) confirmed diagnosis of myelofibrosis (MF) established from 01/01/2018 to 31/12/2027 will be enrolled into the study. Yearly follow-up updates will be scheduled until the end of data collection on 31/12/2028 or until the last available patient visit, whichever comes first. At least 1 year of follow-up will be ensured from the last patient enrolled.

Eligibility

Min Age: 18 YearsMax Age: 100 Years

Inclusion Criteria3

Diagnosis of primary myelofibrosis (PMF) or secondary (i.e., post-ET/PV MF) myelofibrosis according to 2016- or 2022-WHO criteria ascertained between 01/01/2018 and 31/12/2027
Age ≥ 18 years
Signed informed consent where applicable, in line with current European General Data Protection Regulation (GDPR) directives

Exclusion Criteria2

Diagnosis of early/prefibrotic primary myelofibrosis
Concurrent participation to interventional clinical trials in MF

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Locations(36)

Hematology Center after Prof.R.H. Yeolyan

Yerevan, Armenia

University of Copenhagen's Roskilde Hospital

Copenhagen, Denmark

Clinical Investigation Center of the Saint Louis Hospital

Paris, France

Internal Medicine C, Hematology, Oncology, Stem Cell Transplantation and Palliative Care, University Medicine Greifswald

Greifswald, Germany

University Hospital Halle Department of Hematology/Oncology

Halle, Germany

University Clinic for Hematology, Oncology, Hemostaseology and Palliative Care Johannes Wesling Medical Center Minden UKRUB, University of Bochum

Minden, Germany

Division of Haematology, Sasson University Hospital Assuta Ashdod, Ashdod, Ben-Gurion University of Negev

Ashdod, Israel

A.S.O. SS. Antonio e Biagio e C.Arrigo, SC Ematologia

Alessandria, Italy

ASST Papa Giovanni XXIII, SC Ematologia

Bergamo, Italy

Policlinico S. Orsola - Malpighi, Unità di Ematologia

Bologna, Italy

Azienda Ospedaliero - Universitaria "Policlinico Vittorio Emanuele" - PO Gaspare Rodolico, Dipartimento di ematologia con Trapianto di midollo Osseo

Catania, Italy

AOU Careggi di Firenze, Divisione di Ematologia

Florence, Italy

ASST Grande Ospedale Metropolitano Niguarda, Divisione di Ematologia

Milan, Italy

Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, Ematologia

Milan, Italy

Ospedale San Raffaele, Unità Operativa di Ematologia e Trapianto Midollo Osseo

Milan, Italy

Fondazione IRCCS San Gerardo dei Tintori

Monza, Italy

Azienda Ospedaliera Universitaria Federico II, Divisione di Ematologia

Naples, Italy

Azienda Ospedaliero Universitaria Maggiore della Carità, SCDU Ematologia

Novara, Italy

Azienda Ospedale-Università di Padova, Dipartimento di Medicina

Padova, Italy

Università degli Studi di Padova - Policlinico Universitario, Clinica Medica 1

Padova, Italy

Fondazione IRCCS Policlinico San Matteo, Divisione di Ematologia

Pavia, Italy

Fondazione Policlinico Universitario A. Gemelli - Università Cattolica del Sacro Cuore, UCSC Ematologia

Roma, Italy

Policlinico Umberto I, Dipartimento Ematologia, Oncologia e Dermatologia

Roma, Italy

A.O.U. Città della Salute e della Scienza di Torino - Ospedale Molinette- S.C. Ematologia U

Torino, Italy

ASST dei Sette Laghi (Ospedale di Circolo e F. Macchi), Divisione U.O. Ematologia

Varese, Italy

Azienda Ospedaliera Universitaria Integrata - Ospedale Borgo Roma, Unità di Ematologia

Verona, Italy

Azienda ULSS 8 Berica - Ospedale San Bortolo, Divisione di Ematologia

Vicenza, Italy

Institute of Oncology, State University of Medicine and Pharmacy - Department of Oncology, Hematology and Radiotherapy

Chisinau, Moldova

Department of Hematology, University Hospital, Jagiellonian University Medical College

Krakow, Poland

Department and Clinic of Haematology, Blood Neoplasms, and Bone Marrow Transplantation, Wroclaw Medical University

Wroclaw, Poland

Department of Hematology and Bone Marrow Transplantation, Fundeni Clinical Institute

Bucharest, Romania

Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) - Hospital Clinic

Barcelona, Spain

Hematology and Hemotherapy Department, 12 de Octubre University Hospital

Madrid, Spain

Servicio de Hematología - Hospital Clínico Universitario de Valencia

Valencia, Spain

School of Medicine, Dentistry and Biomedical Sciences Queen's University Belfast

Belfast, United Kingdom

Guy's and St. Thomas' NHS Foundation Trust.

London, United Kingdom

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NCT06533813

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