Phase 3 Clinical Trial of Wujia Yizhi Granules in the Treatment of Mild-to-moderate Alzheimer's Dementia (Syndrome of Deficiency of Spleen and Kidney)

This Phase 3 study tests a traditional Chinese herbal medicine called Wujia Yizhi Granules in people with mild-to-moderate Alzheimer's disease. In Traditional Chinese Medicine, this formula is used to address a pattern called "deficiency of spleen and kidney." Researchers want to find out whether this herbal treatment can slow the progression of Alzheimer's symptoms — such as memory loss and daily functioning — compared to a placebo over a set period. **You may be eligible if...** - You are 50 to 80 years old - You have a confirmed diagnosis of Alzheimer's disease of mild-to-moderate severity (MMSE score 11–26, CDR-GS 1–2) - You have had symptoms for more than 6 months - If you lack prior biomarker testing, you have evidence of amyloid buildup in the brain from either a PET scan or cerebrospinal fluid test - You or your legal representative can provide informed consent **You may NOT be eligible if...** - Your memory problems are caused by something other than Alzheimer's (e.g., vascular dementia, Parkinson's, Lewy body disease, thyroid disease, vitamin deficiency) - You have a history of seizures - You have a psychiatric disorder (such as schizophrenia or bipolar disorder) - Your depression score (HAMD-17) is 17 or higher - You are currently taking antidepressants, anti-anxiety drugs, or antipsychotics Talk to your doctor to see if this trial is right for you.