RecruitingPhase 3NCT06535529

Acetazolamide Versus Dapagliflozin in Acute Decompensated Heart Failure Patients


Sponsor

Helwan University

Enrollment

60 participants

Start Date

Aug 24, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this clinical trial is to compare the effectiveness of acetazolamide versus dapagliflozin as an add-on in treating acute decompensated heart failure (ADHF) in adult patients with clinical signs of volume overload requiring intravenous loop diuretics. It will also assess the safety of these drugs when added to standard care. The main questions it aims to answer are: * Does acetazolamide or dapagliflozin lead to a greater reduction in N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels? * Which drug results in better loop diuretic efficiency, as measured by weight loss per 40 mg of intravenous furosemide or equivalent? We will compare acetazolamide to dapagliflozin, both added to standard intravenous loop diuretic therapy, to see which is more effective in decongesting patients with ADHF. Participants will: * Take either acetazolamide or dapagliflozin orally every day for 3 days * Receive intravenous loop diuretics as part of standard care * Undergo regular assessments of heart failure symptoms, weight, and laboratory tests * Be followed up until hospital discharge and for 30 days after starting the study


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This trial compares two diuretic medications — acetazolamide and dapagliflozin — in patients hospitalized with acute heart failure (when the heart suddenly cannot pump well, causing fluid buildup). The goal is to find which drug better removes excess fluid and relieves symptoms. **You may be eligible if...** - You are 18 or older - You are admitted to hospital for worsening heart failure with signs of fluid overload (e.g., leg swelling or fluid around the lungs) - Your heart function has been assessed by imaging in the past year **You may NOT be eligible if...** - You are already on acetazolamide maintenance therapy - You received an SGLT2 inhibitor (a diabetes/heart drug) in the last 48 hours - Your kidney function is severely reduced (eGFR below 20) - You are taking certain other diuretic medications not allowed during the study Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGAcetazolamide

Patients will receive acetazolamide 500 mg once daily for 3 days as add on therapy to IV loop diuretics

DRUGDapagliflozin 10mg

patient will receive oral dapagliflozin 10 mg once daily for 3 days as add on therapy to IV loop diuretics


Locations(1)

Critical Care Medicine Department - Cairo University Hospitals.

Cairo, Egypt

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NCT06535529


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