KetoNiFast: Cyclic Enteral Daytime Feeding With Ketogenic Nighttime Fasting
KetoNiFast: Impact of Cyclic Enteral Daytime Feeding With Ketogenic Nighttime Fasting on Outcome of Critical Ill Patients.
University Hospital of Cologne
130 participants
Sep 1, 2023
INTERVENTIONAL
Conditions
Summary
A physiological human nutrition includes circadian feeding and nighttime fasting during sleep. There is increasing evidence, that this natural fasting episode over nighttime majorly contributes to repair processes of the human body. So far, intensive care patients are normally enterally fed continuously, so that there is no circadian nutrition and no nighttime fasting. An enteral nutrition for 12 hours followed by a fasting period of 12 hours supported by exogenous ketone salts potentially improves the reconstitution of ICU patients compared to ICU patients who are continuously enterally fed.
Eligibility
Inclusion Criteria3
- written informed consent to participate in this study
- admission to ICU
- enteral nutrition
Exclusion Criteria14
- Severe liver dysfunction / liver failure (Child Pugh >7 points / category B)
- Severe kidney dysfunction (KDIGO stage 3)
- Total pancreatectomy / insulin dependent diabetes mellitus (IDDM)
- Pregnancy / lactation
- Hemoglobin concentration < 80g/l
- Severe metabolic disorders / severe autoimmune diseases
- Refractory metabolic or respiratory acidosis
- Dysfunction of mitochondrial transport of fatty acids
- Dysfunction of oxidation of fatty acids
- Dysfunction of gluconeogenesis, production and reduction of ketones
- Intermittent Porphyria
- Severe cardiac arrhythmias / cardiomyopathy
- Contraindication against enteral nutrition
- Lack of informed consent
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Interventions
12 hours of enteral feeding (as per patients´individual calorimetric requirements measured by indirect calorimetry) followed by a fasting period of 12 hours supported by the supplementation of exogenous ketone salts.
Locations(1)
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NCT06535815