RecruitingPhase 3NCT06605144

Canadian Critical Care Comparative Effectiveness Platform

Canadian Critical Care Comparative Effectiveness Platform(e) d'Évaluation Clinique Comparée en Soins Critiques (CEPEC)


Sponsor

Université de Sherbrooke

Enrollment

5,500 participants

Start Date

Mar 23, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The Canadian Critical Care Comparative Effectiveness Platform(e) d'Évaluation Clinique Comparée en soins Critiques (CEPEC) is an international multi-centered randomized adaptive platform clinical trial. CEPEC will evaluate supportive care interventions that are used routinely in intensive care units throughout the world.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying 1- Platelet less than 10 x 109/L, a drug called 1- Vasopressor - Mean arterial pressure 56-60, and others for people with intensive care unit icu, nutrition, and other related conditions. The study is currently recruiting participants at 9 locations. People eligible for this study include aged 18 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUG1- Vasopressor - Mean arterial pressure 56-60

Vasopressor(s) will be titrated according to 56-60 range.

DRUG2- Vasopressor - Mean arterial pressure 61-65

Vasopressor(s) will be titrated according to 61-65 range.

DRUG3- Vasopressor - Mean arterial pressure 66-70

Vasopressor(s) will be titrated according to 66-70 range.

DRUG4- Vasopressor - Mean arterial pressure 71-75

Vasopressor(s) will be titrated according to 71-75 range.

OTHER1- Platelet less than 10 x 109/L

Once randomized, the participant will receive a platelet transfusion if their most recent platelet count is less than 10 x 109/L at the time of the planned procedure.

OTHER2- Platelet less than 20 x 109/L

Once randomized, the participant will receive a platelet transfusion if their most recent platelet count is less than 20 x 109/L at the time of the planned procedure.

OTHER3- Platelet less than 30 x 109/L

Once randomized, the participant will receive a platelet transfusion if their most recent platelet count is less than 30 x 109/L at the time of the planned procedure.

OTHER4- Platelet less than 40 x 109/L

Once randomized, the participant will receive a platelet transfusion if their most recent platelet count is less than 40 x 109/L at the time of the planned procedure.

OTHER5- Platelet less than 50 x 109/L

Once randomized, the participant will receive a platelet transfusion if their most recent platelet count is less than 50 x 109/L at the time of the planned procedure.

OTHEREnteral nutrition - Boluses

Given 3 times a day.

OTHEREnteral nutrition - Continuous

Given over 24-hour period


Locations(9)

Hamilton Health Sciences - Juravinski Hospital

Hamilton, Ontario, Canada

The Ottawa Hospital

Ottawa, Ontario, Canada

Scarborough Health Network

Scarborough Village, Ontario, Canada

Niagara Health

St. Catharines, Ontario, Canada

Sunnybrook Health Sciences Centre

Toronto, Ontario, Canada

Centre hospitalier de l'Université de Montréal (CHUM)

Montreal, Quebec, Canada

CIUSSS de l'Estrie - CHUS

Sherbrooke, Quebec, Canada

Auckland City Hospital

Auckland, New Zealand

Intensive Care National Audit and Research Centre (coordinating centre for sites in UK. Sites to be determined)

London, United Kingdom

View Full Details on ClinicalTrials.gov

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NCT06605144


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