Trigeminal Brainstem Mapping 2: Higher Cortical Strucureas As Well As Subnuclei of the Spinal Trigeminal Nucleus
Brainstem Mapping of Nociceptive and Non-nociceptive Trigeminal Input and Its Functional Connectivty
Universitätsklinikum Hamburg-Eppendorf
40 participants
Aug 1, 2024
INTERVENTIONAL
Conditions
Summary
In previous studies clustering of the three branches of the trigeminal nerve in brainstem were shown, cerebellum and periaqueductal gray. To further evaluate higher cortical structures, which were not covered by our previous field of view (FOV) and to further investigate the identified 'subnuclei' of the spinal trigeminal nucleus, here the aim is to scan the whole brain as well as the brainstem and the upper spinal cord during trigeminal nociceptive as well as non-nociceptive electrical stimulation of all three branches of the trigeminal nerve (and the arm as a somatic control site) during acquisition of BOLD-fMRI in humans.
Eligibility
Inclusion Criteria2
- healthy
- suitable fo MRI
Exclusion Criteria3
- headache disease
- psychological disorder
- pregnancy
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Interventions
Electric stimulation with a Digitimer DS7AH HV Current Stimulator delivered with 4 shielded electrodes mounted on the participants head and arm
Locations(1)
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NCT06535880