Clinical Study Evaluating the Effect of Losartan

This trial is studying whether the blood pressure medication losartan can improve outcomes for people with pancreatic cancer. Lab research suggests that losartan may help chemotherapy drugs reach tumors more effectively. This trial combines losartan with standard chemotherapy to find out if this combination works better than chemotherapy alone. **You may be eligible if...** - You are 50 or older (male or female) with high blood pressure (BP ≥ 140/90) - You have been diagnosed with metastatic or locally advanced pancreatic cancer confirmed by tissue sample **You may NOT be eligible if...** - You have serious heart, kidney, liver, or lung disease - You are pregnant, breastfeeding, or of childbearing potential - You have received fluoropyrimidine-based chemotherapy (like 5-fluorouracil) in the past 10 years - You have had a severe reaction to fluoropyrimidine therapy or are allergic to its components Talk to your doctor to see if this trial is right for you.