RecruitingNot ApplicableNCT06542991

An Open-label Study on the Clinical Efficacy of rTMS Intervention in PD

Sponsor

Anhui Medical University

Enrollment

20 participants

Start Date

Sep 1, 2024

Study Type

INTERVENTIONAL

Conditions

Parkinson Disease Transcranial Magnetic Stimulation Supplementary Motor Area

Summary

To demonstrate that intervention targeting the supplementary motor area (SMA) using precise navigation positioning can effectively improve motor symptoms in patients with Parkinson's disease.

Eligibility

Min Age: 40 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether repetitive transcranial magnetic stimulation (rTMS) — a non-invasive brain stimulation technique that uses magnetic pulses — can help people with Parkinson's disease manage their symptoms. **You may be eligible if...** - You are 40 years or older and have been diagnosed with Parkinson's disease - Your Parkinson's motor symptoms score at least 8 on a standard scale - Your disease severity falls in the mild-to-moderate range (Hoehn-Yahr stage 1–4) - Your thinking and memory are intact enough to complete tests (MMSE score of 24 or above) - Your medications have not changed in the past 4 weeks **You may NOT be eligible if...** - Brain imaging shows significant brain damage or severe white matter disease - You have a secondary form of parkinsonism (e.g., caused by stroke or medications) - You have had brain surgery or deep brain stimulation - You have metal implants in your body such as a cochlear implant or pacemaker Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERtranscranial magnetic stimulation

During treatment, the patient underwent cTBS targeting the left SMA for 7 consecutive days. Each treatment day comprised six rounds of cTBS, with a 15-minute interval between each. A single cTBS session involved trains of three pulses at 50 Hz, repeated every 200 ms (5 Hz), until reaching a total of 600 pulses, lasting 40s. Stimulation intensity remained at 80% of resting motor threshold. In total, patients received 25,200 pulses throughout the treatment period.