RecruitingNot ApplicableNCT06542991

An Open-label Study on the Clinical Efficacy of rTMS Intervention in PD

Sponsor

Anhui Medical University

Enrollment

20 participants

Start Date

Sep 1, 2024

Study Type

INTERVENTIONAL

Conditions

Parkinson Disease Transcranial Magnetic Stimulation Supplementary Motor Area

Summary

To demonstrate that intervention targeting the supplementary motor area (SMA) using precise navigation positioning can effectively improve motor symptoms in patients with Parkinson's disease.

Eligibility

Min Age: 40 Years

Inclusion Criteria5

Age ≥40 years old
Meet Movement Disorder Society standards;
Have no history of drug adjustment within 4 weeks before and during treatment;
The MDS-UPDRS Ⅲ score ≥8, and the Hoehn-Yahr rating is 1-4
MMSE ≥24，able to cooperate with the completion of behavioral tests and transcranial magnetic stimulation therapy.

Exclusion Criteria10

Head MRI/CT ruled out focal brain injury or severe leukoencephalopathy (Fazekas grade 3);
Various secondary parkinsonism syndromes (vascular parkinsonism, Parkinsonism combined with parkinsonism, drug parkinsonism, etc.);
Severe craniocerebral trauma, received craniocerebral surgery or deep brain stimulation treatment;
There are ferromagnetic implants in the body, such as cochlear implants, cardiac pacemakers, etc.
The person or first-degree relatives have a history of epilepsy, unexplained loss of consciousness, or are taking anticonvulsant drugs to treat epileptic seizures;
Diagnosed with a neuropsychiatric disorder other than PD
Have a history of drug abuse or drug use;
Participants in any clinical trial within the previous 6 month;
Pregnant/lactating women or subjects (including men) who have a birth plan within 6 months;
Other conditions deemed unsuitable for inclusion by the investigator.

Interventions

OTHERtranscranial magnetic stimulation

During treatment, the patient underwent cTBS targeting the left SMA for 7 consecutive days. Each treatment day comprised six rounds of cTBS, with a 15-minute interval between each. A single cTBS session involved trains of three pulses at 50 Hz, repeated every 200 ms (5 Hz), until reaching a total of 600 pulses, lasting 40s. Stimulation intensity remained at 80% of resting motor threshold. In total, patients received 25,200 pulses throughout the treatment period.