Azithromycin Before Induction
Azithromycin to Prevent Chorioamnionitis in Women Undergoing Induction of Labor, a Randomized Control Trial
Arrowhead Regional Medical Center
400 participants
Aug 7, 2023
INTERVENTIONAL
Conditions
Summary
This is a double blinded randomized control trial involving administration of 2 grams prophylactic azithromycin in third trimester patients undergoing induction of labor at our institution to demonstrate reduction in maternal and neonatal infection.
Eligibility
Inclusion Criteria7
- Third trimester of pregnancy defined as 28 0/7 weeks or more
- Singleton pregnancy
- Age 18-45
- Induction of labor initiated for medical or obstetrical reason or electively over 39 weeks of gestation
- No contraindication to vaginal delivery
- Reassuring fetal heart rate tracing
- Able and willing to provide informed consent
Exclusion Criteria7
- Does not read or write in English or Spanish
- Unable or unwilling to give informed consent
- Use of antibiotic or antiviral agent within the last 7 days
- Evidence of active infection at the time of initiation of induction (patients with rectovaginal group B streptococcus positive results will be allowed to participate as it is a colonizing organism, unless they show evidence of active infection)
- Incarcerated Women
- Active substance abuse
- Age < 18
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Interventions
Azithromycin 2 grams to be administered prior to start of induction for those randomized to intervention group
4 magnesium oxide tablets prior to the start of induction for those randomized to placebo
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06543290