RecruitingPhase 1NCT06544265

SynKIR-310 for Relapsed/Refractory B-NHL

A Phase 1 Study of SynKIR-310, Autologous T Cells Transduced With CD19 KIR-CAR, in Participants With Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma


Sponsor

Verismo Therapeutics

Enrollment

36 participants

Start Date

Nov 1, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

This first-in-human (FIH) trial is designed to assess the safety, feasibility and preliminary efficacy of a single intravenous (IV) dose of SynKIR-310 administered to participants with relapsed/refractory B-NHL.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a new cell therapy called SynKIR-310 for people with B-cell non-Hodgkin lymphoma (B-NHL) whose cancer has come back or stopped responding to previous treatments. **You may be eligible if...** - You are 18 or older with confirmed B-cell non-Hodgkin lymphoma - Your cancer has returned or stopped responding after at least 2 prior treatments - You have received or were unable to receive CAR T-cell therapy before - If you had a stem cell transplant, it was at least 6 months ago and you have no active graft-versus-host disease - You have measurable disease on imaging **You may NOT be eligible if...** - You have active serious infections or uncontrolled autoimmune disease - You have active hepatitis B or C - You have major organ failure or other conditions that would make participation unsafe Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BIOLOGICALSynKIR-310

Autologous T Cells transduced with CD19 KIR-CAR


Locations(5)

Colorado Blood Cancer Institute, part of Sarah Cannon Cancer Institute

Denver, Colorado, United States

Winship Cancer Institute of Emory University

Atlanta, Georgia, United States

The University of Kansas Cancer Center

Fairway, Kansas, United States

Rutgers Cancer Institute

New Brunswick, New Jersey, United States

Abramson Cancer Center of the University of Pennsylvania

Philadelphia, Pennsylvania, United States

View Full Details on ClinicalTrials.gov

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NCT06544265


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