RecruitingPhase 1NCT06544655

A Study of BMS-986484 Alone and Combination Therapy in Participants With Advanced Solid Tumors

A Phase 1/1b First-in-human Trial of BMS-986484 as Monotherapy and Combination Therapy in Participants With Advanced Solid Malignancies


Sponsor

Bristol-Myers Squibb

Enrollment

213 participants

Start Date

Oct 10, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

The purpose of this study is to assess the safety and tolerability of BMS-986484 administered alone, in combination with nivolumab in participants with advanced/metastatic solid tumors including non-small cell lung cancer (NSCLC), microsatellite stable (MSS) colorectal carcinoma (CRC), pancreatic ductal adenocarcinoma (PDAC), gastric/gastroesophageal junction adenocarcinoma (G/GEJC), and squamous cell carcinoma of the head and neck (SCCHN).


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a new drug called BMS-986484, alone or in combination with other treatments, in people with several types of advanced solid tumors — including lung, pancreatic, stomach, colorectal, and head and neck cancers. **You may be eligible if...** - You have advanced, metastatic, or recurrent non-small cell lung cancer, pancreatic cancer, gastric/gastroesophageal junction cancer, MSS colorectal cancer, or head and neck squamous cell carcinoma - You have measurable tumors on scans - You are in reasonably good physical condition (ECOG 0–1) **You may NOT be eligible if...** - You have active lung scarring or interstitial lung disease - You have an active autoimmune disease - You have serious uncontrolled medical conditions - You have had a recent blood clot Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGBMS-986484

Specified dose on specified days

BIOLOGICALNivolumab

Specified dose on specified days

DRUGOxaliplatin

Specified dose on specified days

DRUGCapecitabine

Specified dose on specified days

DRUGFluorouracil

Specified dose on specified days

DRUGCalcium folinate

Specified dose on specified days


Locations(11)

University of Arizona Cancer Center

Tucson, Arizona, United States

USC/Norris Comprehensive Cancer Center

Los Angeles, California, United States

START Midwest

Grand Rapids, Michigan, United States

Sanford Cancer Center

Sioux Falls, South Dakota, United States

NEXT Oncology

San Antonio, Texas, United States

St Vincent's Hospital

Darlinghurst, New South Wales, Australia

Lyell McEwin Hospital

Elizabeth Vale, South Australia, Australia

Princess Margaret Cancer Centre

Toronto, Ontario, Canada

Centre Hospitalier de l'Université de Montréal

Montreal, Quebec, Canada

Local Institution - 0023

Chuo-ku, Tokyo, Japan

Local Institution - 0022

Kashiwa, Japan

View Full Details on ClinicalTrials.gov

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NCT06544655


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