Microsampling for Therapeutic Drug Monitoring of Oral Oncolytics in Oncology Patients
Microsampling to Facilitate Drug Monitoring of Oncolytics
Leiden University Medical Center
360 participants
Oct 6, 2025
INTERVENTIONAL
Conditions
Summary
The aim of the study is to perform a clinical validation of the analytical method for dried blood spot microsampling of cabozantinib, pazopanib, sunitinib, lenvatinib, imatinib, abiraterone, enzalutamide, nivolumab, ipilimumab, pembrolizumab, atezolizumab, bevacizumab or enfortumab vedotin. The secondary objective is to test the feasibility of home monitoring (microsampling TDM) of cabozantinib, pazopanib, sunitinib, lenvatinib, imatinib, abiraterone, enzalutamide, nivolumab, ipilimumab, pembrolizumab, atezolizumab, bevacizumab or enfortumab vedotin in oncology patients.
Eligibility
Inclusion Criteria3
- Willing and able to provide informed consent;
- years of age or older;
- Using one or more of the following drugs: Cabozantinib, Pazopanib, Sunitinib, Lenvatinib, Imatinib, Abiraterone, Enzalutamide, Nivolumab, Ipilimumab, Pembrolizumab, Atezolizumab, Bevacizumab or Enfortumab vedotin
Exclusion Criteria1
- Not able to sample themselves using a finger prick
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Interventions
Patients who use an oral oncolytic will be asked to provide four paired whole blood (WB) samples obtained by venapuncture.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06545292