Ocular Perfusion in Patients With Idiopathic Intracranial Hypertension
Medical University of Vienna
48 participants
May 28, 2024
OBSERVATIONAL
Conditions
Summary
The proposed study aims to evaluate optic nerve head blood flow and microcirculation in patients with idiopathic intracranial hypertension. For this purpose, optic nerve head blood flow will be examined in patients with IIH before and after therapy and additionally compared with healthy age- and sex-matched control subjects. In addition, other parameters will be measured, in particular retinal blood flow, retinal oxygen saturation and retinal neurovascular coupling.
Eligibility
Inclusion Criteria9
- Men and Women aged ≥ 18 years
- Signed informed consent
- Newly diagnosed idiopathic intracranial hypertension or relapse of idiopathic intracranial hypertension
- Non-Smokers
- Men and Women aged ≥ 18 years
- Signed informed consent
- Normal ophthalmic findings, unless the investigator considers an abnormality to be clinically irrelevant
- Normal findings in the medical history, unless the investigator considers an abnormality to be clinically irrelevant
- Non-Smokers
Exclusion Criteria11
- Blood donation in the three weeks preceding the study
- Symptoms of a clinically relevant illness in the three weeks preceding the study
- Ocular inflammation or infection within the last 3 months
- History or family history of epilepsy
- Diabetes mellitus type 1 or type 2
- History or known presence of other cerebral vascular diseases (e.g.: arteriovenous malformation, aneurysm, major artery stenosis or occlusion)
- History or known presence of intracranial infections (e.g.: meningitis)
- History or known presence of other neurological diseases (e.g.: brain tumor, hydrocephalus, degenerative diseases)
- Patients receiving corticosteroids or immunosuppressant therapy
- Pregnant or breast-feeding women
- Women of childbearing potential (neither menopausal, nor hysterectomized, nor sterilized) not using effective contraception
Interventions
Patients with idiopathic intracranial hypertension will receive lumbar puncture and will be given medication to reduce intracranial pressure by neurologists. The lumbar puncture and the administration of medication are not part of this study, patients would also receive these without participating in the study.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06545981