Dietary Intervention on Atopy
National University of Singapore
110 participants
May 10, 2024
INTERVENTIONAL
Conditions
Summary
Diet is a key determinant of overall health, with growing evidence associating dietary patterns with allergic diseases. Among these, atopic dermatitis (AD) is of particular interest as it often represents the earliest manifestation of the atopic triad. Investigating dietary interventions in AD therefore provides a relevant model to better understand how diet may influence the onset and progression of allergic disease more broadly.
Eligibility
Inclusion Criteria11
- Presence of current, mild-to-moderate atopic dermatitis/eczema at flexural areas
- to 65 years of age (inclusive) at screening
- Must be English-literate and able to give informed consent in English
- Be residing in Singapore and will not be travelling outside of Singapore during the study period
- Reliable and willing to follow study procedures and be available for the duration of the study
- Non-smokers (tobacco and e-cigarette)
- Non-drinker (no regular or frequent consumption of alcohol)
- Overtly healthy with no pre-existing medical conditions (e.g., diabetes, hypertension, cancer, blood disorders, degenerative/liver/autoimmune/immune/renal diseases, or psychiatric conditions)
- No food allergies to test foods
- No needle phobia
- Be willing to follow the instruction provided by the investigators on the use of any moisturiser, cosmetics, and/or topical cream on the skin throughout the entire duration of the study.
Exclusion Criteria14
- Concurrent participation in other research studies
- Pregnancy or lactating individuals
- Known or ongoing psychiatric disorders within 3 years
- Known severe nutritional deficiency
- Vegetarian/vegans (as meat will be included in the diet)
- Individuals who made a significant dietary change in the past 12 months
- Having a pre-existing dietary restriction that would interfere with the adherence to a whole diet meal
- Regular use of strong medication (western and/or traditional), therapies, and alternative medications
- Regular nutritional supplements in the past 12 months Regular consumption of oral contraceptive pills and/or steroid hormones
- Antibiotic use in the past 2 months
- Any long-term hospitalisation or surgery during the 6 months before enrolment in study
- Significant change in weight (+/- 5.0%) during the past month
- History of bleeding diathesis or coagulopathy (or any bleeding disorders)
- Having donated blood of more than 500 mL within 4 weeks of study enrolment
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Interventions
The primary aim of this dietary intervention study is to assess the effectiveness of a dietary pattern characterized by lower saturated fats, higher wholegrains, fruit, and vegetables in reducing the severity of AD in young Singapore adults, as measured by changes in Scoring Atopic Dermatitis (SCORAD) scores, over a 2-month intervention period.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06547372