RecruitingNot ApplicableNCT06547398

Prostate Adaptive Radiation Therapy

Sponsor

Royal North Shore Hospital

Enrollment

130 participants

Start Date

Oct 1, 2025

Study Type

INTERVENTIONAL

Conditions

Prostatic Neoplasms

Summary

Prostate ART is a two phase study looking at using adaptive radiotherapy to help reduce toxicity for prostate cancer patients. Adaptive radiotherapy is a new technology that provides the ability to account for daily changes in anatomy. Adaptive radiotherapy also provides a foundation for which radiotherapy margins might be safely reduced. Phase 1 of this study is looking to see if a radiation therapist centred adaptive workflow can be implemented. If phase 1 of this study is safe and feasible, the study will proceed to phase 2. Part 2 of the study looks at using adaptive technology to reduce radiation treatment margins. The primary aim of this study is to see whether margin reduced treatment using adaptive radiotherapy can reduce side effects for prostate cancer patients.

Eligibility

Sex: MALEMin Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing an advanced, adaptive form of radiation therapy for prostate cancer. Unlike standard radiation, adaptive radiation therapy adjusts the treatment plan in real time based on changes in the prostate's shape and position during treatment. The goal is to deliver more precise radiation while reducing damage to nearby healthy tissue. **You may be eligible if...** - You are over 18 years old - You have been diagnosed with prostate cancer confirmed by biopsy - Your treatment plan calls for radiation therapy to the prostate only (not other areas) - You are in reasonably good physical health and able to go through with the treatment **You may NOT be eligible if...** - You have a hip replacement (prosthesis) on either side - The distance from the center of your prostate to the edge of your body exceeds a certain measurement that would make precise imaging difficult Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

RADIATIONAdaptive radiotherapy +/- Margin Reduction

Radiotherapy using adaptive technology to recontour and replan daily as required. Reductions in the PTV margin will also be introduced in the second phase of this study.

RADIATIONImage guided radiotherapy

Standard radiation treatment used in the department of radiation oncology for prostate cancer

Locations(1)

Northern Sydney Cancer Centre, Royal North Shore Hospital

St Leonards, New South Wales, Australia

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NCT06547398

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