RecruitingNot ApplicableNCT06547827

Rehabilitation With and Without Robot and Allied Digital Technologies in Stroke Patients

Rehabilitation With and Without Robot and Allied Digital Technologies (RADTs) in Stroke Patients: a Pragmatic Multicenter Randomised Controlled Trial on the Effectiveness, Acceptability, Usability, and Economic-organizational Sustainability of RADTs From Subacute to Chronic Phase


Sponsor

Fondazione Don Carlo Gnocchi Onlus

Enrollment

596 participants

Start Date

Aug 12, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

Rehabilitation after stroke often employs Robot and Allied Digital Technologies (RADTs), yet evidence on their effectiveness remains inconclusive due to study heterogeneity and limited sample sizes. This multicentre randomized controlled pragmatic trial aims at comprehensively and accurately assessing the effectiveness of rehabilitation mediated by RADTs after a stroke, compared to traditional rehabilitation, also considering economic sustainability.


Eligibility

Min Age: 18 Years

Inclusion Criteria5

  • First-ever diagnosis of ischemic or haemorrhagic stroke confirmed by Computed Tomography or Magnetic Resonance Imaging;
  • Age 18 years and over;
  • Time since the event equal to or less than 6 months;
  • Mild to severe impairment of the upper limb (motor section of the Fugl-Meyer Assessment of Upper Extremity ≤ 58) and/or mild to severe impairment of the lower limb (score on the Functional Ambulation Categories scale ≤ 4) and/or mild to severe impairment of balance (Berg Balance Scale ≤ 45);
  • Clinical stability allowing transfer to the gym and execution of the planned treatments.

Exclusion Criteria6

  • Clinical instability;
  • Behavioral/cognitive disorders preventing adequate patient compliance with both traditional and robotic rehabilitation treatment (severe cognitive deficit, Montreal Cognitive Assessment <10);
  • Rigidity or hypertonia (Modified Ashworth Scale > 3) in the plegic/paretic limb;
  • Serious uncorrectable visual impairments preventing the patient from performing treatment with technological and/or robotic devices;
  • Pregnant women;
  • Refusal to sign the informed consent.

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Interventions

OTHERrobotic rehabilitation

Treatment will occur in a gym equipped with devices for all the domains, with two physiotherapists supervising groups of 4 to 6 patients, depending on their clinical severity. Patients will undergo a total of 25 sessions, each lasting 45 minutes, with the following frequency: * 5 times a week for 5 weeks, for inpatients; * 3 times a week for 8.3 weeks, for outpatients.

OTHERtraditional rehabilitation

A physiotherapist-to-patient ratio of 1:1 is provided for the treatment in all participating centres. Patients will undergo a total of 25 sessions, each lasting 45 minutes, with the following frequency: * 5 times a week for 5 weeks, for inpatients; * 3 times a week for 8.3 weeks, for outpatients.


Locations(13)

Fondazione Don Carlo Gnocchi, Centro Gala

Acerenza, Italy

IRCCS Istituti Clinici Scientifici Maugeri

Bari, Italy

IRCCS Ospedale Policlinico San Martino,

Genova, Italy

Fondazione Don Carlo Gnocchi, IRCCS Santa Maria Nascente

Milan, Italy

IRCCS Istituti Clinici Scientifici Maugeri

Milan, Italy

IRCCS Istituti Clinici Scientifici Maugeri

Montescano, Italy

IRCCS Fondazione Mondino

Pavia, Italy

IRCCS Istituti Clinici Scientifici Maugeri

Pavia, Italy

Fondazione Don Carlo Gnocchi, Centro Santa Maria della Provvidenza

Roma, Italy

Fondazione Don Carlo Gnocchi, Centro Santa Maria al Mare

Salerno, Italy

Fondazione Don Carlo Gnocchi, Polo Specialistico Riabilitativo

Sant'Angelo dei Lombardi, Italy

IRCCS Istituti Clinici Scientifici Maugeri

Telese Terme, Italy

Fondazione Don Carlo Gnocchi, Polo specialistico riabilitativo

Tricarico, Italy

View Full Details on ClinicalTrials.gov

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NCT06547827


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