RecruitingPhase 2NCT06548542

Study of Targeted Therapies for the Treatment of Adult Participants With Moderate to Severe Crohn's Disease

A Phase 2a Multicenter, Randomized, Platform Study of Targeted Therapies for the Treatment of Adult Subjects With Moderate to Severe Crohn's Disease

Sponsor

AbbVie

Enrollment

540 participants

Start Date

Sep 4, 2024

Study Type

INTERVENTIONAL

Conditions

Crohn's Disease

Summary

Crohn's disease (CD) is a long-lasting disease that causes severe inflammation (redness, swelling), in the digestive tract, most frequently affecting the bowels. It can cause many different symptoms including belly pain, diarrhea, tiredness, and weight loss. Treatments are available but do not work the same for all patients or may stop working over time. This study will evaluate the effectiveness and adverse events of targeted therapies (TaTs) for adult participants with moderate to severe CD. The medicines assessed in this study are risankizumab, trosunilimab, lutikizumab, and ABBV-8736. When participants join the study, they will be randomized into available study treatment groups. Adult participants with CD will be enrolled. Around 540 participants will be enrolled in the study at approximately 300 sites worldwide. Risankizumab and trosunilimab are given as an injection under the skin or as an infusion into the vein. Lutikizumab is given as an injection under the skin. ABBV-8736 is given as an infusion into the vein. There may be higher treatment burden for participants in this trial compared to their standard of care treatment without participating in this study. Participants will attend regular visits during the study at a hospital or clinic. The effect of the treatment will be checked by medical assessments, blood tests, endoscopies, checking for side effects and completing questionnaires and a daily diary.

Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study is testing targeted treatments for adults with moderate to severe Crohn's disease — a chronic condition that causes inflammation in the digestive tract, leading to pain, diarrhea, and other symptoms. The trial matches patients with specific therapies based on their medical history and prior treatment responses. **You may be eligible if...** - You weigh at least 40 kg - You have been confirmed to have Crohn's disease for at least 3 months - Your symptoms score is above a certain level on standard scales (indicating moderate to severe disease) - An endoscopy shows active inflammation in your gut - You have not responded well or have become intolerant to conventional treatments and/or prior biologic or targeted therapies **You may NOT be eligible if...** - You have had a previous bad reaction to the specific class of drugs used in this study (p19 inhibitors) - You have active serious infections, including tuberculosis - You have recently received certain other treatments - You are pregnant or breastfeeding - You have certain other conditions that make these medications unsafe for you Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGRisankizumab

Subcutaneous Injection

DRUGLutikizumab

Subcutaneous Injection

DRUGTrosunilimab

Intravenous Infusion

DRUGRisankizumab

Intravenous Infusion

DRUGTrosunilimab

Subcutaneous Injection

DRUGABBV-8736

Intravenous Infusion

Locations(254)

Digestive Health Specialists /ID# 266216

Dothan, Alabama, United States

East View Medical Research /ID# 270377

Mobile, Alabama, United States

Southern California Res. Ctr /ID# 265549

Coronado, California, United States

UC San Diego Health System /ID# 265565

La Jolla, California, United States

uc davis medical center - patient support services building /ID# 265554

Sacramento, California, United States

Clinical Applications Laboratories - San Diego - 3rd Avenue /ID# 267391

San Diego, California, United States

Peak Gastroenterology Associates - Colorado Springs - North Cascade Avenue /ID# 265557

Colorado Springs, Colorado, United States

Danbury Hospital, Western Connecticut Health Network /ID# 265556

Danbury, Connecticut, United States

Yale University School of Medicine /ID# 266786

New Haven, Connecticut, United States

Novum Research /ID# 278128

Clermont, Florida, United States

University of Florida College of Medicine /ID# 266930

Gainesville, Florida, United States

Nature Coast Clinical Research - Inverness /ID# 265874

Inverness, Florida, United States

Atlantic Medical Research /ID# 266207

Margate, Florida, United States

A Plus Research /ID# 265878

Miami, Florida, United States

Sanchez Clinical Research /ID# 265887

Miami, Florida, United States

Advanced Research Institute, Inc /ID# 265548

New Port Richey, Florida, United States

Hillcrest Medical Research, LLC /ID# 267237

Orange City, Florida, United States

Endoscopic Research, Inc. /ID# 267211

Orlando, Florida, United States

Gcp Clinical Research /ID# 278126

Tampa, Florida, United States

AdventHealth Medical Group - Tampa - Bruce B Downs Boulevard /ID# 265538

Tampa, Florida, United States

Florida Medical Clinic - Zephyrhills /ID# 267392

Zephyrhills, Florida, United States

Gastroenterology Associates of Central Georgia /ID# 265547

Macon, Georgia, United States

Treasure Valley Medical Research /ID# 267114

Boise, Idaho, United States

University of Chicago Medical Center /ID# 267400

Chicago, Illinois, United States

OSF St. Francis Medical Center /ID# 266973

Peoria, Illinois, United States

Springfield Clinic Main Campus /ID# 267434

Springfield, Illinois, United States

Indiana University Health University Hospital /ID# 278129

Indianapolis, Indiana, United States

University of Kentucky Chandler Medical Center. /ID# 265564

Lexington, Kentucky, United States

Metropolitan Gastroenterology Group - Chevy Chase /ID# 265877

Chevy Chase, Maryland, United States

Lucida Clinical Trials /ID# 266548

New Bedford, Massachusetts, United States

Henry Ford Medical Center - Columbus /ID# 266503

Novi, Michigan, United States

Mayo Clinic-Rochester /ID# 265550

Rochester, Minnesota, United States

GI Associates Research, LLC /ID# 267433

Columbia, Missouri, United States

BVL Clinical Research /ID# 265870

Liberty, Missouri, United States

Washington University School of Medicine - St. Louis /ID# 266938

St Louis, Missouri, United States

Vector Clinical Trials /ID# 265561

Las Vegas, Nevada, United States

NYU Langone Long Island Clinical Research Association /ID# 265566

Great Neck, New York, United States

Icahn School of Medicine at Mount Sinai /ID# 266857

New York, New York, United States

Northwell Health-Lenox Hill Hospital /ID# 265527

New York, New York, United States

Care Access - Yonkers /ID# 266781

Yonkers, New York, United States

Digestive Health Partners - Biltmore Office /ID# 265539

Asheville, North Carolina, United States

Velocity Clinical Research - Durham /ID# 267712

Durham, North Carolina, United States

University of Cincinnati /ID# 265589

Cincinnati, Ohio, United States

The Ohio State University /ID# 265577

Columbus, Ohio, United States

Digestive Disease Specialists - Oklahoma /ID# 265901

Oklahoma City, Oklahoma, United States

Penn State Health Milton South Hershey Medical Center /ID# 267126

Hershey, Pennsylvania, United States

University of Pennsylvania /ID# 265904

Philadelphia, Pennsylvania, United States

Gastroenterology Associates of Orangeburg /ID# 267548

Orangeburg, South Carolina, United States

GI associates of Northeast Tennessee /ID# 265567

Johnson City, Tennessee, United States

Gi Alliance - Cedar Park /ID# 268153

Cedar Park, Texas, United States

Proactive Clinical Research /ID# 267305

El Paso, Texas, United States

Digestive Health Associates of Texas (DHAT) Research Institute - Garland /ID# 266935

Garland, Texas, United States

Houston Methodist Hospital /ID# 265533

Houston, Texas, United States

Caprock Gastro Research - Lubbock - 80th Street /ID# 265541

Lubbock, Texas, United States

GI Alliance: Mansfield /ID# 266947

Mansfield, Texas, United States

Clinical Associates in Research Therapeutics of America, LLC /ID# 265899

San Antonio, Texas, United States

Sun Research Institute /ID# 266723

San Antonio, Texas, United States

Southern Star Research Institute /ID# 278124

San Antonio, Texas, United States

Texas Digestive Disease Consultants - Southlake /ID# 265576

Southlake, Texas, United States

Tyler Research Institute, LLC /ID# 265545

Tyler, Texas, United States

Care Access - Ogden /ID# 266428

Ogden, Utah, United States

Care Access - Salt Lake City /ID# 266785

Salt Lake City, Utah, United States

Virginia Mason Hospital & Medical Center /ID# 265574

Seattle, Washington, United States

Washington Gastroenterology - Tacoma /ID# 267302

Tacoma, Washington, United States

Medizinische Universitaet Graz /ID# 275453

Graz, Styria, Austria

Medizinische Universitaet Innsbruck /ID# 265930

Innsbruck, Tyrol, Austria

Ordensklinikum Linz GmbH Barmherzige Schwestern /ID# 265929

Linz, Upper Austria, Austria

Klinikum Wels-Grieskirchen GmbH /ID# 266035

Wels, Upper Austria, Austria

Landeskrankenhaus Salzburg-Universitaetsklinikum der PMU (LKH) /ID# 265928

Salzburg, Austria

Medizinische Universitaet Wien /ID# 265926

Vienna, Austria

Imelda Ziekenhuis /ID# 265995

Bonheiden, Antwerpen, Belgium

Universite Libre de Bruxelles - Hopital Erasme /ID# 265993

Anderlecht, Brussels Capital, Belgium

CHU Saint-Pierre /ID# 266431

Brussels, Brussels Capital, Belgium

Cliniques Universitaires UCL Saint-Luc /ID# 265521

Brussels, Brussels Capital, Belgium

Groupe Sante CHC - Clinique du MontLegia /ID# 265522

Liège, Liege, Belgium

Universite Catholique de Louvain-Namur - Centre Hospitalier Universitaire Dinant /ID# 265517

Yvoir, Namur, Belgium

Universitair Ziekenhuis Leuven /ID# 265519

Leuven, Vlaams-Brabant, Belgium

AZ Groeninge /ID# 265544

Kortrijk, West-Vlaanderen, Belgium

AZ Oostende /ID# 275534

Ostend, West-Vlaanderen, Belgium

CHU de Liege /ID# 265542

Liège, Belgium

Hospital Tsaritsa Yoanna /ID# 266235

Sofiya, Sofia, Bulgaria

Medical Center - Doverie /ID# 267050

Sofiya, Sofia, Bulgaria

ACIBADEM City Clinic Diagnostic-Consultative Center /ID# 266239

Sofiya, Sofia, Bulgaria

Umbal Kaspela /ID# 266234

Plovdiv, Bulgaria

MHAT Knyaginya Klementina /ID# 266238

Sofia, Bulgaria

Acibadem City Clinic Tokuda University Hospital EAD /ID# 267437

Sofia, Bulgaria

Military Medical Academy Multiprofile Hospital /ID# 267051

Sofia, Bulgaria

UMHAT Multiprofile Hospital for Active Treatment Sveta Marina /ID# 266237

Varna, Bulgaria

University of Calgary /ID# 265524

Calgary, Alberta, Canada

Gastroenterology and Internal Medicine Research Institute /ID# 265610

Edmonton, Alberta, Canada

University of Alberta Hospital /ID# 265614

Edmonton, Alberta, Canada

Medicor Research /ID# 267405

Greater Sudbury, Ontario, Canada

London Health Sciences Centre - University Hospital /ID# 267298

London, Ontario, Canada

Toronto Digestive Disease Associates /ID# 267358

Vaughan, Ontario, Canada

Clinique IMD /ID# 272057

Montreal, Quebec, Canada

Diex Recherche Quebec Inc. /ID# 265611

Québec, Canada

Klinicki Bolnicki Centar Zagreb /ID# 265502

Grad Zagreb, City of Zagreb, Croatia

Poliklinika Solmed /ID# 265509

Zagreb, City of Zagreb, Croatia

Poliklinika Borzan d.o.o. /ID# 265503

Osijek, County of Osijek-Baranja, Croatia

Specialty Hospital Medico /ID# 265504

Rijeka, Primorje-Gorski Kotar County, Croatia

Klinicki Bolnicki Centar (KBC) Split /ID# 265511

Split, Split-Dalmatia County, Croatia

Hepato-Gastroenterologie HK /ID# 265387

Hradec Králové, Hradec Kralove, Czechia

Iscare Klinické Centrum /ID# 265407

Prague, Praha 9, Czechia

SurGal Clinic /ID# 265388

Brno, South Moravian, Czechia

Aarhus Universitetshospital - Skejby /ID# 269064

Aarhus, Central Jutland, Denmark

Odense University Hospital /ID# 267778

Odense, Region Syddanmark, Denmark

Medicum /ID# 268304

Tallinn, Harju, Estonia

East Tallinn Central Hospital /ID# 267658

Tallinn, Estonia

Tartu University Hospital /ID# 267656

Tartu, Estonia

Tampere University Hospital /ID# 267721

Tampere, Pirkanmaa, Finland

Turku University Hospital /ID# 267723

Turku, Southwest Finland, Finland

Chu de Nice-Hopital Larchet Ii /Id# 267478

Nice, Alpes-Maritimes, France

CHU de Toulouse - Hôpital Rangueil /ID# 267479

Toulouse, Haute-Garonne, France

CHU de Montpellier - Hopital Saint Eloi /ID# 265718

Montpellier, Herault, France

Centre Hospitalier Universitaire de Rennes - Hopital Pontchaillou /ID# 266848

Rennes, Ille-et-Vilaine, France

Centre Hospitalier Régional Universitaire de Nancy - Hôpitaux de Brabois /ID# 265703

Vandœuvre-lès-Nancy, Meurthe-et-Moselle, France

Centre Hospitalier Universitaire de Bordeaux /ID# 265721

Pessac, New Aquitaine, France

Centre Hospitalier Universitaire de Saint Etienne - Hopital Nord /ID# 265340

St-Priest-en-Jarez, Pays de la Loire Region, France

Hospices Civils de Lyon - Centre Hospitalier Lyon-Sud /ID# 266851

Pierre-Bénite, Rhone, France

Clinique Jules Verne /ID# 267480

Nantes, France

Hopital Saint Antoine /ID# 265725

Paris, France

Universitaetsklinikum Freiburg /ID# 265755

Freiburg im Breisgau, Baden-Wurttemberg, Germany

Universitaetsmedizin Mannheim /ID# 266961

Mannheim, Baden-Wurttemberg, Germany

Universitaetsklinikum Ulm /ID# 266962

Ulm, Baden-Wurttemberg, Germany

Universitaetsklinikum Erlangen /ID# 265927

Erlangen, Bavaria, Germany

Klinikum der Universitaet Muenchen Grosshadern /ID# 269165

Munich, Bavaria, Germany

Universitaetsklinikum Regensburg /ID# 275556

Regensburg, Bavaria, Germany

Markus Krankenhaus /ID# 265938

Frankfurt am Main, Hesse, Germany

Universitaetsklinikum Frankfurt /ID# 266827

Frankfurt am Main, Hesse, Germany

Klinikum Lueneburg /ID# 266886

Lüneburg, Lower Saxony, Germany

Universitaetsmedizin Essen /ID# 275535

Essen, North Rhine-Westphalia, Germany

St. Marien- und St. Annastiftskrankenhaus /ID# 265912

Ludwigshafen am Rhein, Rhineland-Palatinate, Germany

Universitaetsklinikum des Saarlandes /ID# 265753

Homburg, Saarland, Germany

Universitaetsklinikum Carl Gustav Carus Dresden /ID# 265931

Dresden, Saxony, Germany

Eugastro /ID# 266826

Leipzig, Saxony, Germany

Studiengesellschaft BSF Unternehmergesellschaft /ID# 265751

Halle, Saxony-Anhalt, Germany

Universitaetsklinikum Schleswig-Holstein - Campus Kiel /ID# 265738

Kiel, Schleswig-Holstein, Germany

Universitaetsklinikum Schleswig-Holstein Campus Luebeck /ID# 267254

Lübeck, Schleswig-Holstein, Germany

Charite Universitaetsmedizin Berlin - Campus Mitte /ID# 265752

Berlin, Germany

DRK Kliniken Berlin - Westend /ID# 265925

Berlin, Germany

Krankenhaus Waldfriede /ID# 266676

Berlin, Germany

Debreceni Egyetem-Klinikai Kozpont /ID# 267389

Debrecen, Hajdú-Bihar, Hungary

Clinfan /ID# 267385

Szekszárd, Tolna County, Hungary

Synexus Hungary Clinical Research Centre - Budapest /ID# 267384

Budapest, Hungary

Semmelweis Egyetem /ID# 267064

Budapest, Hungary

Semmelweis Egyetem /ID# 267068

Budapest, Hungary

Szegedi Tudomanyegyetem /ID# 267386

Szeged, Hungary

Letterkenny General Hospital /ID# 276677

Letterkenny, Donegal, Ireland

Portiuncula University Hospital /ID# 267771

Ballinasloe, Galway, Ireland

Our Lady of Lourdes Hospital - Drogheda /ID# 267768

Drogheda, Louth, Ireland

Midland Regional Hospital Mullingar /ID# 267769

Mullingar, Westmeath, Ireland

St. Vincent's University Hospital /ID# 267766

Dublin, Ireland

Beaumont Hospital /ID# 267770

Dublin, Ireland

Connolly Hospital /ID# 268021

Dublin, Ireland

Edith Wolfson Medical Center /ID# 267640

Holon, Central District, Israel

Soroka Medical Center /ID# 267235

Beersheba, Southern District, Israel

Tel Aviv Sourasky Medical Center /ID# 267307

Tel Aviv, Tel Aviv, Israel

Rambam Health Care Campus- Haifa /ID# 267641

Haifa, Israel

Azienda Ospedaliero Universitaria di Cagliari - P.O. Duilio Casula /ID# 267287

Monserrato, Cagliari, Italy

Fondazione di Religione e di Culto Casa Sollievo della Sofferenza /ID# 267143

San Giovanni Rotondo, Foggia, Italy

IRCCS Istituto Clinico Humanitas /ID# 265946

Rozzano, Lombardy, Italy

IRCCS Ospedale San Raffaele /ID# 265951

Milan, Milano, Italy

Azienda Ospedaliera Universitaria Policlinico Tor Vergata /ID# 265935

Rome, Roma, Italy

Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Universita Cattolica /ID# 265940

Rome, Roma, Italy

A.O. Ordine Mauriziano di Torino /ID# 267144

Turin, Torino, Italy

IRCCS Ospedale Sacro Cuore Don Calabria /ID# 265942

Negrar, Verona, Italy

Azienda Ospedaliero-Universitaria Renato Dulbecco /ID# 267722

Catanzaro, Italy

Azienda Ospedaliera Universitaria Gaetano Martino /ID# 267145

Messina, Italy

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico /ID# 265949

Milan, Italy

Liepaja Regional Hospital /ID# 267703

Liepāja, Latvia

Pauls Stradins Clinical University Hospital /ID# 267705

Riga, Latvia

Digestive Diseases Center GASTRO /ID# 267707

Riga, Latvia

Hospital of Lithuanian University of Health Sciences Kaunas Clinics /ID# 267695

Kaunas, Lithuania

Panevezys Republican Hospital /ID# 267709

Panevezys, Lithuania

Vilnius University Hospital Santaros Klinikos /ID# 267711

Vilnius, Lithuania

Elisabeth TweeSteden Ziekenhuis /ID# 265729

Tilburg, North Brabant, Netherlands

Amsterdam UMC, locatie AMC /ID# 268321

Amsterdam, North Holland, Netherlands

Universitair Medisch Centrum Groningen /ID# 265736

Groningen, Netherlands

Universitair Medisch Centrum Utrecht /ID# 265731

Utrecht, Netherlands

Akershus University Hospital /ID# 267642

Lørenskog, Akershus, Norway

Helse More- og Romsdal HF, Alesund sjukehus /ID# 267632

Ålesund, Møre og Romsdal, Norway

Oslo Universitetssykehus Ulleval /ID# 267630

Oslo, Norway

NZOZ Centrum Medyczne KERmed /ID# 266766

Bydgoszcz, Kuyavian-Pomeranian Voivodeship, Poland

Gastromed Sp. z o.o /ID# 266765

Torun, Kuyavian-Pomeranian Voivodeship, Poland

Malopolskie Centrum Kliniczne /ID# 265943

Krakow, Lesser Poland Voivodeship, Poland

Medical Network Sp.z.o.o. WIP Warsaw IBD Point Profesor Kierkus /ID# 266764

Warsaw, Masovian Voivodeship, Poland

Bodyclinic Sp. z o.o. sp.k. /ID# 265945

Warsaw, Masovian Voivodeship, Poland

Endoskopia Sp. z.o.o. /ID# 265934

Sopot, Pomeranian Voivodeship, Poland

H-T Centrum Medyczne Endoterapia /ID# 265937

Tychy, Silesian Voivodeship, Poland

Polimedica PTG Kielce /ID# 267066

Kielce, Świętokrzyskie Voivodeship, Poland

Unidade Local de Saude do Alto Ave, EPE /ID# 265892

Guimarães, Braga District, Portugal

2CA-Braga, Hospital de Braga /ID# 265894

Braga, Portugal

Unidade Local de Saude de Coimbra, EPE /ID# 267240

Coimbra, Portugal

Unidade Local de Saude de Lisboa Ocidental, EPE /ID# 267242

Lisbon, Portugal

Unidade Local de Saude de Santa Maria, EPE /ID# 266113

Lisbon, Portugal

Unidade Local de Saude do Alto Minho, EPE - Hospital de Santa Luzia /ID# 265885

Viana do Castelo, Portugal

Memorial Healthcare International S.R.L. /Id# 267328

Bucharest, Bucharest, Romania

Spitalul Clinic Colentina /ID# 267208

Bucharest, Bucharest, Romania

Clinica Gastro Med SRL /ID# 267204

Cluj-Napoca, Cluj, Romania

OncoHelp Association /ID# 267203

Timișoara, Timiș County, Romania

Clinical Hospital Center Zvezdara /ID# 265605

Belgrade, Beograd, Serbia

Military Medical Academy /ID# 267452

Belgrade, Beograd, Serbia

University Clinical Hospital Center "Dr. Dragisa Misovic - Dedinje" /ID# 265607

Belgrade, Beograd, Serbia

Clinical Hospital Center - Bežanijska Kosa /ID# 265604

Belgrade, Beograd, Serbia

Leskovac General Hospital /ID# 265606

Leskovac, Jablanicki Okrug, Serbia

General Hospital Djordje Joanovic /ID# 266040

Zrenjanin, Vojvodina, Serbia

University Clinical Center Vojvodina /ID# 265603

Novi Sad, Serbia

Mount Elizabeth Hospital /ID# 268354

Singapore, Central Singapore, Singapore

Gleneagles Hospital /ID# 268385

Singapore, Central Singapore, Singapore

National University Hospital /ID# 268128

Singapore, Singapore

Fakultna nemocnica s poliklinikou F.D. Roosevelta Banska Bystrica /ID# 266064

Banská Bystrica, Banská Bystrica Region, Slovakia

KM Management, spol. s.r.o. /ID# 266070

Nitra, Nitra Region, Slovakia

Gastro I., s.r.o. /ID# 267159

Prešov, Presov, Slovakia

ENDOMED s.r.o /ID# 266068

Košice, Slovakia

General Hospital Celje /ID# 267699

Celje, Slovenia

University Medical Centre Ljubljana /ID# 267697

Ljubljana, Slovenia

Inje University Haeundae Paik Hospital /ID# 266380

Busan, Busan Gwang Yeogsi, South Korea

Dong-A University Medical Center /ID# 266709

Busan, Busan Gwang Yeogsi, South Korea

The Catholic University of Korea, Daejeon St. Mary's Hospital /ID# 265488

Daejeon, Daejeon Gwang Yeogsi, South Korea

Chungang University Hospital /ID# 266427

Dongjak-gu, Seoul Teugbyeolsi, South Korea

Samsung Medical Center /ID# 265489

Seoul, Seoul Teugbyeolsi, South Korea

Kyungpook National University Chilgok Hospital /ID# 265487

Daegu, South Korea

Complejo Hospitalario Universitario de Santiago (CHUS) /ID# 266902

Santiago de Compostela, A Coruna, Spain

Hospital Universitario Virgen Macarena /ID# 266648

Seville, Sevilla, Spain

Hospital Universitario Virgen del Rocio /ID# 266727

Seville, Sevilla, Spain

Hospital Clinic de Barcelona /ID# 265415

Barcelona, Spain

Hospital Universitario 12 de Octubre /ID# 265444

Madrid, Spain

Hospital Universitario La Paz /ID# 265412

Madrid, Spain

Hospital Alvaro Cunqueiro /ID# 266647

Pontevedra, Spain

Hospital Universitari i Politècnic La Fe /ID# 265478

Valencia, Spain

University Hospital Zurich /ID# 275755

Zurich, Canton of Zurich, Switzerland

Inselspital, Universitaetsspital Bern /ID# 265733

Bern, Switzerland

Intesto /ID# 265728

Bern, Switzerland

China Medical University Hospital /ID# 265924

Taichung, Taiwan

National Taiwan University Hospital /ID# 265921

Taipei, Taiwan

Taipei Veterans General Hospital- Taipei City /ID# 276064

Taipei, Taiwan

Linkou Chang Gung Memorial Hospital /ID# 265922

Taoyuan City, Taiwan

Kocaeli University Research and Application Hospital /ID# 267772

Dilovası, Kocaeli, Turkey (Türkiye)

Hacettepe Universitesi Tip Fakultesi /ID# 266394

Ankara, Turkey (Türkiye)

Bezmialem Vakif Üniversitesi /ID# 266399

Istanbul, Turkey (Türkiye)

Istanbul University Istanbul Medical Faculty /ID# 266299

Istanbul, Turkey (Türkiye)

Karadeniz Teknik Universitesi Tip Fakultesi /ID# 266303

Trabzon, Turkey (Türkiye)

Western General Hospital - NHS Lothian /ID# 266333

Edinburgh, Edinburgh, City of, United Kingdom

Gartnavel General Hospital /ID# 266407

Glasgow, Glasgow City, United Kingdom

Barts Health NHS Trust /ID# 266410

London, Greater London, United Kingdom

Royal Free Hospital /ID# 268065

London, Greater London, United Kingdom

Guy's Hospital /ID# 266336

London, Greater London, United Kingdom

St George University Hospitals NHS Foundation Trust /ID# 266335

London, Greater London, United Kingdom

The John Radcliffe Hospital /ID# 266334

Oxford, Oxfordshire, United Kingdom

The Royal Wolverhampton NHS Trust /ID# 268158

Guildford, Surrey, United Kingdom

University Hospital Coventry & Warwickshire NHS Trust /ID# 267128

Coventry, Warwickshire, United Kingdom

Velocity Clinical Research - Bristol /ID# 275736

Bristol, United Kingdom

University Hospital of Wales /ID# 275702

Cardiff, United Kingdom

Royal Victoria Infirmary /ID# 268064

Newcastle upon Tyne, United Kingdom

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NCT06548542

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