RecruitingNCT06550102

Drug Response Profiling (DRP) Registry Zurich for Hematological Malignancies


Sponsor

University Children's Hospital, Zurich

Enrollment

1,000 participants

Start Date

Jan 4, 2022

Study Type

OBSERVATIONAL

Conditions

Summary

This study is a prospective, non-randomized feasibility study of drug response profiling (DRP) in pediatric blood cancers. Primary cancer cells are isolated from patients and screened ex vivo at single-cell resolution using automated fluorescence microscopy. Drug sensitivity fingerprints are integrated with genetic annotations to inform the treating physician about personalized treatment options. The study aims to determine the practicability of real-time drug response profiling and its actionability in identifying patient-specific cancer dependencies in refractory disease settings.


Eligibility

Max Age: 40 Years

Plain Language Summary

Simplified for easier understanding

This is a registry study collecting tumor samples from patients with blood cancers — such as leukemia, lymphoma, or myeloma — to study how cancer cells respond to different drugs in a lab setting. This approach, called drug response profiling (DRP), aims to help doctors predict which treatments will be most effective for individual patients. **You may be eligible if...** - You are under 40 years old - You have been diagnosed with a blood cancer (leukemia, lymphoma, or myeloma) — whether newly diagnosed, relapsed, or treatment-resistant - Tumor material has been collected as part of your routine care and you are willing to donate it for research - You or your guardian have signed a consent form for either this registry or a clinical trial that includes DRP research **You may NOT be eligible if...** - You have not signed the required informed consent - You are 40 years of age or older Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Locations(1)

University Children's Hospital Zurich

Zurich, Canton of Zurich, Switzerland

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NCT06550102


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