RecruitingNCT06553131

Median Versus Ulnar Nerve Quantitative Electromyography Neuromuscular Blockade Monitoring Comparison


Sponsor

Loma Linda University

Enrollment

32 participants

Start Date

Dec 26, 2024

Study Type

OBSERVATIONAL

Conditions

Summary

Medications used to relax the muscles are used during surgery. The amount of muscle relaxation can monitored with devices that stimulate a specific nerve and evaluate the muscle response. The response to, and recovery from, medications that relax the muscles are best described for a nerve in the arm called the ulnar nerve. The investigators believe that other nerves in the arm, such as the median nerve, could be used to monitor the amount of muscle relaxation. The purpose of this study is to compare the muscle response at two different nerve sites after giving medications to relax the muscles. This study is going to measure the depth of muscle relaxation during surgery at two different sites. The muscle response to stimulation of the ulnar nerve (located in the arm) will be compared to the muscle response to stimulation of the median nerve (also located in the arm).


Eligibility

Min Age: 18 YearsMax Age: 75 Years

Inclusion Criteria2

  • Adults 18 - 75 years of age who are able to provide consent
  • Scheduled for elective surgery requiring muscle relaxation, in a supine position under general anesthesia, with an anticipated duration of at least 1.5 hours

Exclusion Criteria9

  • Contraindication to rocuronium use
  • Comorbidities that may prolong the duration of neuromuscular blockade or alter pharmacodynamics and/or pharmacokinetics, such as:
  • Neuromuscular disease
  • Expected or known difficult airway
  • Rocuronium allergy
  • BMI \< 18.5 or \> 40
  • History of adhesive allergy
  • Upper extremity weakness, limb deformity, or absence of all or part of an upper limb
  • Patients undergoing surgical procedures requiring cardiopulmonary bypass

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Interventions

DEVICENeuromuscular Transmission Monitoring

A neuromuscular transmission module connected to electrodes applied to the skin and positioned to provide stimulation of a single nerve and monitor the muscular response to nerve stimulation


Locations(1)

Loma Linda University Troesch Medical Center

Loma Linda, California, United States

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NCT06553131


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