Blinatumomab Plus Venetoclax Sequenced With Inotuzumab Ozogamicin in Treating B-ALL
The Regimen of Blinatumomab and Venetoclax Sequenced With Inotuzumab Ozogamicin in Treating Precursor B Cell Acute Lymphoblastic Leukemia: A Phase II, Single Arm and Multicenter Study
First Affiliated Hospital of Zhejiang University
20 participants
Aug 15, 2024
INTERVENTIONAL
Conditions
Summary
Precursor B cell acute lymphoblastic leukemia (B-ALL) is an aggressive type of leukemia, with high relapse rate and poor long term survival in adults. Traditional treatment regimens mainly include chemotherapy and hematopoietic stem cell transplantation. In the past decade, with the application of molecular targeted drugs and immunotherapy, the survival of B-ALL patients has significantly improved. In this study，we propose a treatment approach that combines Blinatumomab and Venetoclax sequenced with Inotuzumab Ozogamicin in B-ALL adults. Our study aims to answer the safety and efficacy of this treatment regimen, and further improve the survival for those participants.
Eligibility
Inclusion Criteria7
- Before enrollment, a diagnosis of newly diagnosed precursor B-cell acute lymphoblastic leukemia with Philadelphia chromosome-negative must be confirmed. The diagnostic criteria refer to the 2022 WHO classification.
- Age ≥ 40 years;
- Eastern Cooperative Oncology Group (ECOG) performance status score of 0-2;
- Expected survival time ≥ 3 months;
- No organ dysfunction that would restrict the use of this protocol during the screening period;
- Understand the study and sign the informed consent form.
- Men, women of childbearing age (only postmenopausal women who have been menopausal for at least 12 months can be considered infertile), and their partners voluntarily take effective contraceptive measures deemed effective by the investigator during the treatment period and for at least 12 months after the last dose of the study drug.
Exclusion Criteria8
- Patients with known central nervous system (CNS) involvement of ALL;
- Diseases with abnormal heart, lung, liver, kidney, or other organ functions that may limit the patient's participation in this trial (including but not limited to severe infections, uncontrolled diabetes, severe heart failure or angina, active pulmonary tuberculosis, asthma, COPD, bronchiectasis, etc.);
- Cardiac ultrasound LVEF \< 45%;
- History of other malignancies within the past 5 years, excluding localized thyroid cancer and in situ skin cancer;
- Serum total bilirubin \> 1.5 ULN (upper limit of normal); ALT or AST \> 2.5 ULN; serum creatinine \> 1.5 ULN;
- Known HIV infection;
- Conditions affecting the use of the study drug as assessed by the investigator;
- Inability to understand or comply with the study protocol.
Interventions
Glucocorticoids
Bi-specific anti CD19/CD3 antibody
BCL-2 inhibotor
a humanized monoclonal antibody-drug conjugate targeting CD22
antifolate antineoplastic drug
antitumor drug
Pyrimidine, antimetabolites
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06554626