Cardio and Renovascular Effects of Isometric Exercise in the Healthy Human Measured by PET/CT and MRI
Cardio and Renovascular Effects of Static Muscle Work in the Healthy Human - Measured With Finapres® and Positron Emission Tomography (PET) Using 15-oxygen Labeled Water as Tracer Compared to Magnetic Resonance (MR)
Bispebjerg Hospital
10 participants
May 7, 2024
INTERVENTIONAL
Conditions
Summary
This randomized crossover study aims to validate measurements of renal perfusion in healthy males with PET/CT, using 15-oxygen labeled water as tracer, against the validated multiparametric MRI technique. The study will determine: * Total renal blood flow and regional renal perfusion at baseline (rest) and during isometric muscle exercise of the upper arm, using PET/CT (with 15-oxygen labeled water as a tracer) and MRI. * The coefficient of variation of renal blood flow and regional renal perfusion measurements at baseline and during isometric muscle exercise of the upper arm, using PET/CT (with 15-oxygen labeled water as a tracer) and MRI. * Regional renal oxygenation and oxygen extraction at baseline and during isometric muscle exercise of the upper arm using MRI. * The coefficient of variation on regional renal oxygenation and oxygen extraction measurements at baseline and during isometric muscle exercise of the upper arm using MRI.
Eligibility
Inclusion Criteria1
- Normal health stated through medical questionnaire, examination and blood samples.
Exclusion Criteria8
- Immunosuppressive treatment
- Alcohol abuse
- Treatment with glucocorticoids, Glucagon-like peptide-1 (GLP-1) agonists, dipeptidyl peptidase 4 (DPP-4)-inhibitors
- Medical treatment affecting insulin secretion or cardiovascular endpoints
- Liver disease
- Decreased kidney function
- Severe claustrophobia
- Elements incompatible with MR.
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Interventions
MRI will be performed
PET/CT will be performed
Locations(1)
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NCT06555211