RecruitingPhase 1NCT06555393

Understanding the Health Effect of a Bioactive Peptide From Egg: A Pilot Study

A Preliminary Human Study on Bioavailability and Efficacy of Bioactive Peptide IRW in Egg White Hydrolysate


Sponsor

University of Alberta

Enrollment

28 participants

Start Date

Feb 25, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

Bioactive peptides derived from food proteins show potential for improving human health. One of such promising peptides is namely IRW made from egg white hydrolysate and composed of three peptides. This is a feasibility study to assess the acute effect of IRW in egg white hydrolysate for the management of high sugar and blood pressure. Participants at high risk of type 2 diabetes (T2D) or having T2D will undergo 4 consecutive treatments of 1 day each (randomly), during which they will consume a standardized breakfast with a smoothie containing different protein powders. Each treatment will be separated by a minimum of 1-week. Participants in the healthy control group will undergo 1 treatment only (one day).


Eligibility

Min Age: 18 YearsMax Age: 70 Years

Plain Language Summary

Simplified for easier understanding

This study is looking at whether a specific protein found in eggs can help improve blood pressure and blood sugar levels. Researchers are recruiting both healthy adults and people at risk for diabetes or who already have type 2 diabetes to compare how the egg protein affects different groups. **You may be eligible if...** - You are between 18 and 70 years old and live near Edmonton, Canada - You are either in good health with normal weight, OR you are overweight and have elevated blood sugar or are at risk for diabetes - Your weight has been stable for at least 6 months - You are a non-smoker or a long-term former smoker **You may NOT be eligible if...** - You are currently pregnant or planning to become pregnant - You are taking medications that affect blood sugar or blood pressure - You have an active digestive, kidney, liver, or heart condition - You have a known egg allergy - You have already been diagnosed with diabetes (for the healthy control group) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DIETARY_SUPPLEMENTEgg White Powder

Participants will consume a standardized breakfast (2 slices of 70 g whole wheat bread, 10 g of butter and 30 g of strawberry jam) followed by a smoothie containing the powder. The Egg White Powder will be incorporated in the standardized smoothie containing water, fruits and chocolate/strawberry syrup totaling 250 Kcal. The total calories of the breakfast will be adapted to the calorie needs of each participant to account for 20-25% of their daily calorie intake. After a 9 h fast, blood will be taken before consumption of the standardized breakfast and smoothie (T= 0) and at 5, 10, 20, 30, 60, 90, 120, and 180 min after consumption of the smoothie. Participants will be given 15-25 minutes to eat their breakfast. Urine samples will be collected from participants before the smoothie consumption (0 h) and at 30 min, 90 min, 150 min, 6 hours, 12 hours, and 24 hours following consumption.


Locations(1)

University of Alberta

Edmonton, Alberta, Canada

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT06555393


Related Trials