A Prospective, Open-label, Randomized Controlled, Multicenter Clinical Study of Haplo-HSCT Using a TBI or TMLI Conditioning Regimen for Pediatric ALL

This study is comparing two types of full-body radiation preparation methods (total body irradiation vs. a more targeted approach called TMLI) before a stem cell transplant from a half-matched family donor (haploidentical transplant) for children aged 1–17 with acute lymphoblastic leukemia (ALL) that is in remission. **You may be eligible if...** - You are a child aged 1–17 with a confirmed diagnosis of ALL - Your leukemia is in complete remission before the transplant - You have a suitable half-matched (haploidentical) family donor available - Your heart, liver, kidneys, and lungs are functioning adequately **You may NOT be eligible if...** - Your leukemia is not in complete remission at the time of transplant - You do not have a suitable haploidentical donor - You have serious organ dysfunction that prevents transplant - Your guardians or you (if older) are unable or unwilling to provide informed consent Talk to your doctor to see if this trial is right for you.