Development of Novel Psychological Assessment Tools and Anxiety Intervention for Phenylketonuria

This study develops and tests new psychological assessment tools and a brief anxiety-reduction therapy program specifically designed for young people aged 10–17 who have phenylketonuria (PKU), a metabolic condition requiring a strict lifelong diet, and who experience anxiety or depression. **You may be eligible if...** - You are a young person aged 10–17 with a confirmed PKU diagnosis, along with at least one parent or guardian - You were identified through newborn screening with a high phenylalanine blood level and started treatment within 30 days of birth - You or your parent reports interest in a short therapy program for anxiety or depression - You live in Missouri, Kansas, or Illinois **You may NOT be eligible if...** - You have a significant intellectual disability or language difficulties that would prevent therapy participation - You plan to receive other psychotherapy during the study - You plan to change your psychiatric or PKU medications during the study - You have active thoughts of suicide requiring immediate treatment Talk to your doctor to see if this trial is right for you.