RecruitingNot ApplicableNCT06560749

Physical Exercise for Cognitive Rehabilitation of Patients With Bipolar Affective Disorder

Physical Exercise for Cognitive Rehabilitation of Patients With Bipolar Affective Disorder: a Controlled and Randomized Study


Sponsor

Beny Lafer

Enrollment

72 participants

Start Date

Aug 20, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this clinical trial is to evaluate the impact of Physical Exercise (PE), as an adjuvant treatment, on the cognition of patients diagnosed with Bipolar Disorder who present cognitive impairments, as well as its impact on quality of life and functionality and its association with physiological variables. Our specific goals are: 1. Evaluate the effect of PE on the neuropsychological functions of attention, memory, verbal fluency, executive function and processing speed in patients diagnosed with BD who present cognitive impairments in these domains. 2. To evaluate the effect of PE on the quality of life and functionality of patients diagnosed with BD, as well as possible associations with cognitive functions. 3. To evaluate possible correlations between physiological variables, such as cardiorespiratory indices, strength and body composition, and improvements in cognitive functions, quality of life and functionality.


Eligibility

Min Age: 18 YearsMax Age: 60 Years

Inclusion Criteria9

  • Diagnosis of Bipolar disorder (BD) I and II according to DSM-5
  • Age: 18 - 55 years old
  • Complete primary education
  • Euthymic (YMRS < 8 and MADRS < 12)
  • Presence of cognitive impairments (COBRA > 14 and SCIP < 75)
  • Estimated IQ ≥ 80
  • No medication changes in the last month
  • Having been without regular PE practice for six months
  • Signature of the TCLE

Exclusion Criteria4

  • Organic mental disorder
  • BMI > 40
  • Alcohol or drug abuse in the last 6 months
  • Use of benzodiazepines or beta-blockers in the last month

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Interventions

OTHERPhysical Exercise

Measure the impact of physical exercise in the cognition of pacients diagnosed with Bipolar Disorder


Locations(1)

Gabriel Okawa Belizario

São Paulo, São Paulo, Brazil

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NCT06560749


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