Personalized Volume-deescalated Elective Nodal Irradiation in Oropharyngeal Head and Neck Squamous Cell Carcinoma

This study is testing whether a more targeted, personalized approach to radiation therapy for throat cancer (specifically the tonsils, base of tongue, or back of the throat) can reduce side effects by treating fewer lymph nodes — only those at highest risk — rather than the entire neck region. **You may be eligible if...** - You have been newly diagnosed with squamous cell carcinoma (a type of throat cancer) of the oropharynx (tonsils, base of tongue, throat walls) - You have not had any prior treatment for this cancer - You are age 18 or older - You are in reasonably good general health (able to care for yourself with minimal assistance) - You have had a recent PET scan or contrast MRI of the area - Radiation therapy (with or without chemotherapy) is part of your planned treatment **You may NOT be eligible if...** - Your tumor extends significantly beyond the throat into the mouth, nose, or lower throat - You have cancer that has spread to distant parts of the body - You have had prior surgery, chemotherapy, or radiation for other head and neck cancers - You are pregnant or breastfeeding - You have a serious mental condition that affects your ability to make medical decisions Talk to your doctor to see if this trial is right for you.