RecruitingPhase 3NCT06563388

Stereotactic Ablative Radiotherapy (SABR) for the Treatment of Patients With Metastatic Cancer, ID-COMET Trial

(ID-COMET) A Randomized Phase III Trial of Immediate Versus Six-Month Delayed Comprehensive Treatment of 1-10 Oligometastatic Tumors With or Without Synchronous Primary


Sponsor

Roswell Park Cancer Institute

Enrollment

800 participants

Start Date

Sep 18, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

This protocol is comprised of three unblinded, randomized, single-center studies to evaluate the impact of immediate versus three-month delayed comprehensive ablative treatment on survival in newly diagnosed metastatic patients with lung (Trial 1), colorectal (Trial 2), and prostate (Trial 3) cancers


Eligibility

Min Age: 1 Year

Plain Language Summary

Simplified for easier understanding

This study is testing whether a focused, high-dose radiation technique called stereotactic ablative radiotherapy (SABR) — which targets individual tumor spots with great precision — can help patients with a limited number of metastases (cancer spread to 1–10 sites) live longer when added to standard treatment. **You may be eligible if...** - You are age 1 or older - You have lung, prostate, or colorectal cancer that has spread to 1–10 places in the body (or any cancer type for the 4th trial group) - Your cancer has been recently assessed with imaging within the past few months - You are in reasonably good health overall **You may NOT be eligible if...** - You have signs of interstitial lung disease (scarring in the lungs) on prior CT scans — if uncertain, a lung specialist must clear you first - You are pregnant - Your cancer has spread to more than 10 sites (for the first three groups) - Your general health status is too poor to tolerate radiotherapy Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDUREStereotactic Ablative Radiotherapy

Radiation therapy begins after 3 months of Standard of care

OTHERBest Practice

Receive standard of care therapy


Locations(1)

Roswell Park Comprehensive Cancer Center

Buffalo, New York, United States

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NCT06563388


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