A Study Comparing Personalized Radiation Therapy With Standard Radiation Therapy in People With HPV-Positive Throat Cancer

This study is comparing a personalized, lower-dose radiation therapy approach to standard radiation for people with HPV-related throat cancer. Because HPV-associated throat cancers tend to respond better to treatment, researchers want to see if reducing the radiation dose maintains effectiveness while causing fewer side effects. **You may be eligible if...** - You have been diagnosed with HPV-positive squamous cell carcinoma of the oropharynx (tonsils, base of tongue, or throat walls), or a squamous cell cancer with unknown primary site - Your cancer is at an early to intermediate stage with no distant spread - You are age 18 or older - You are in good general health (ECOG 0–1 or KPS ≥70) - You have adequate blood counts and kidney function **You may NOT be eligible if...** - Your cancer has spread to distant organs - You have significant kidney problems or very low blood counts - You are pregnant - Your cancer is HPV-negative Talk to your doctor to see if this trial is right for you.